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Article Dans Une Revue Andrologie Année : 2009

Genetic analysis of human male infertility

Anomalies génétiques et infertilité masculine

Résumé

Fifteen percent of couples are infertile and in about 50% of cases the cause is of male origin. The aetiology is still unknown in more than 90% of cases and there may be genetic or environmental causes. Three approaches are used to detect genetic causes for male infertility: 1) cytogenetics, resulting in particular from progress made in molecular cytogenetics and the direct analysis of gametes by in situ molecular hybridation techniques. When a chromosome anomaly, the most common cause of infertility, including deletion of the Y chromosome, is discovered, it is not easy to distinguish between gene anomalies resulting from change and mechanical anomalies that are an integral part of meiosis; 2) the analysis of candidate genes, which often uses data obtained from animal, usually murine, models. This approach, frequently described in the literature, tends to be lengthy, expensive and rarely results in the discovery of an abnormal gene, as is the case, for example, with meiotic genes; 3) Mendel’s approach is clearly the preferred choice, studying as it does cases of inherited infertility, which is much more widespread than we might think.
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Dates et versions

hal-02656888 , version 1 (30-05-2020)

Identifiants

  • HAL Id : hal-02656888 , version 1
  • PRODINRA : 31311

Citer

François Vialard, Béatrice Mandon-Pepin, F. Pellestor, A. Ziyyat, M. Albert, et al.. Anomalies génétiques et infertilité masculine. Andrologie, 2009, 19, pp.2-16. ⟨hal-02656888⟩
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