Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Virology Année : 2008

Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin

Résumé

For influenza viruses to become infectious, the proteolytic cleavage of hemagglutinin (HA) is essential. This usually is mediated by trypsin-like proteases in the respiratory tract. The binding of plasminogen to influenza virus A/WSN/33 leads to the cleavage of HA, a feature determining its pathogenicity and neurotropism in mice. Here, we demonstrate that plasminogen also promotes the replication of other influenza virus strains. The inhibition of the conversion of plasminogen into plasmin blocked influenza virus replication. Evidence is provided that the activation of plasminogen is mediated by the host cellular protein annexin II, which is incorporated into the virus particles. Indeed, the inhibition of plasminogen binding to annexin II by using a competitive inhibitor inhibits plasminogen activation into plasmin. Collectively, these results indicate that the annexin II-mediated activation of plasminogen supports the replication of influenza viruses, which may contribute to their pathogenicity.

Domaines

Virologie

Dates et versions

hal-02660726 , version 1 (30-05-2020)

Identifiants

Citer

Fanny Le Bouder, Eric E. Morello, Guus Rimmelzwaan, Francoise Bosse, Christine Péchoux, et al.. Annexin II incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin. Journal of Virology, 2008, 82 (14), pp.6820-6828. ⟨10.1128/JVI.00246-08⟩. ⟨hal-02660726⟩
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