A. A. Amali, C. J. Lin, Y. H. Chen, W. L. Wang, H. Y. Gong et al., Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish, 2004.

, Dev. Dynamics, vol.229, pp.847-856

H. Amthor, G. Nicholas, I. Mckinnell, C. F. Kemp, M. Sharma et al., Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis, Dev. Biol, vol.270, pp.19-30, 2004.

H. Amthor, A. Otto, A. Vulin, A. Rochat, J. Dumonceaux et al., Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity, Proc. Nat. Acad. Sci, vol.106, pp.7479-7484, 2009.

J. N. Artaza, S. Bhasin, C. Mallidis, W. Taylor, K. Ma et al., Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells, J. Cell. Physiol, vol.190, pp.170-179, 2002.

J. N. Artaza, S. Bhasin, T. R. Magee, S. Reisz-porszasz, R. Q. Shen et al., Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells, Endocrinology, vol.146, pp.3547-3557, 2005.

A. J. Bailey, M. B. Enser, E. Dransfield, D. J. Restall, and N. C. Avery, Muscle and adipose tissue from normal and double muscled cattle: collagen types, muscle fiber diameter, fat cell size and fatty acid composition and organoleptic properties, Current Topics in Veterinary Medicine and Animal Science, Martinus Nijhoff, vol.16, pp.178-204, 1982.

R. H. Bellinge, D. A. Liberles, S. P. Iaschi, A. A. O'brien, and G. K. Tay, Myostatin and its implications on animal breeding: a review, Anim. Genet, vol.36, pp.1-6, 2005.

R. Bischoff and C. Heintz, Enhancement of skeletal-muscle regeneration, Dev. Dynamics, vol.201, pp.41-54, 1994.

S. Bogdanovich, T. O. Krag, E. R. Barton, L. D. Morris, L. A. Whittemore et al., Functional improvement of dystrophic muscle by myostatin blockade, Nature, vol.420, pp.418-421, 2002.

J. Bouley, B. Meunier, C. Chambon, D. Smet, S. Hocquette et al., Proteomic analysis of bovine skeletal muscle hypertrophy, Proteomics, vol.5, pp.490-500, 2005.
URL : https://hal.archives-ouvertes.fr/hal-02680776

C. J. Carlson, F. W. Booth, and S. E. Gordon, Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading, Regulatory Integrative and Comparative Physiology, vol.277, pp.601-606, 1999.

I. Cassar-malek, F. Passelaigue, and C. Bernard,

J. Leger and J. F. Hocquette, Target genes of myostatin loss-of-function in muscles of late bovine fetuses, BMC Genomics, vol.8, p.63, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02664722

C. Charlier, W. Coppieters, F. Farnir, L. Grobet, P. L. Leroy et al., The mh gene causing double-muscling in cattle maps to bovine Chromosome 2, Mammal. Genome, vol.6, pp.788-792, 1995.

I. Chelh, Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin, p.114, 2009.

I. Chelh, B. Meunier, B. Picard, M. J. Reecy, C. Chevalier et al., Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets, BMC Genomics, vol.10, 0196.
URL : https://hal.archives-ouvertes.fr/hal-02658841

Y. W. Chen, C. M. Gregory, M. T. Scarborough, R. Shi, G. A. Walter et al., Transcriptional pathways associated with skeletal muscle disuse atrophy in humans, Physiol. Genomics, vol.31, pp.510-520, 2007.

A. Clinquart, J. L. Hornick, C. Van-eenaeme, and L. Istasse, Le caractère culard en Blanc Bleu Belge. INRA Prod. Anim, vol.11, pp.285-297, 1998.

A. Clop, F. Marcq, H. Takeda, D. Pirottin, X. Tordoir et al., A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep, Nature Genetics, vol.38, pp.813-818, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02669134

G. Culley, Observations on livestock, 1807.

E. Th, U. K. London, and G. Woodfall, , pp.1735-1813

V. Deveaux, Influence du facteur de croissance Myostatine sur la prolifération et la différenciation des cellules musculaires bovines, 2002.

E. Thèse, I. I. Doctorale-clermont, V. Deveaux, B. Picard, J. Bouley et al., Location of myostatin expression during bovine myogenesis in vivo and in vitro, Reprod. Nutr. Dev, vol.43, pp.527-542, 2003.

A. C. Durieux, A. Amirouche, S. Banzet, N. Koulmann, R. Bonnefoy et al.,

C. Mouret, X. Bigard, A. Peinnequin, and D. Freyssenet, Ectopic expression of myostatin induces atrophy of adult skeletal muscle by decreasing muscle gene expression, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00387979

, Endocrinology, vol.148, pp.3140-3147

R. E. Ferrell, V. Conte, E. C. Lawrence, S. M. Roth, J. M. Hagberg et al., Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of musclerelated phenotypes, Genomics, vol.62, pp.203-207, 1999.

D. Forbes, M. Jackman, A. Bishop, M. Thomas, R. Kambadur et al., Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism, J. Cell Physiol, vol.206, pp.264-272, 2006.

H. Gagnière, B. Picard, C. Jurie, and Y. Geay, Comparative study of metabolic differentiation of foetal muscle in normal and doublemuscled cattle, Meat Sci, vol.45, pp.145-152, 1997.

D. K. Garikipati, S. A. Gahr, and B. D. Rodgers, Identification, characterization, and quantitative expression analysis of rainbow trout myostatin-1a and myostatin-1b genes, J. Endocrinol, vol.190, pp.879-888, 2006.

D. K. Garikipati, S. A. Gahr, E. H. Roalson, and B. D. Rodgers, Characterization of rainbow trout myostatin-2 Genes (rtMSTN-2a and -2b): Genomic organization, differential expression, and pseudogenization, Endocrinology, vol.148, pp.2106-2115, 2007.

M. Georges, L. Grobet, D. Poncelet, L. J. Royo, D. Pirottin et al., Positional candidate cloning of the bovine mh locus identifies an allelic series of mutations disrupting the myostatin function and causing double muscling in cattle. In: Quantitative genetic theory; selection theory and experiments; internationalisation of breeding programs; detection of quantitative trait loci, 1998.

, quantitative trait loci maps; transgenics; developmental genetics, Proc. 6 th World Congr, pp.195-202

K. Yarasheski, I. Sinha-hikim, K. Ma, S. Ezzat, R. Shen et al., Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting, Proc. Nat. Acad. Sci, vol.95, pp.14938-14943, 1998.

L. Grobet, L. J. Martin, D. Poncelet, D. Pirottin, B. Brouwers et al., A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle, Nature Genet, vol.17, pp.71-74, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02686447

L. Grobet, D. Poncelet, L. J. Royo, B. Brouwers, D. Pirottin et al., Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle, Mammalian Genome, vol.9, pp.210-213, 1998.
URL : https://hal.archives-ouvertes.fr/hal-02695193

L. Grobet, D. Pirottin, F. Farnir, D. Poncelet, L. J. Royo et al., Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene, Genesis, vol.35, pp.227-238, 2003.

T. Guo, W. Jou, T. Chanturiya, J. Portas, O. Gavrilova et al., Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity, PLoS One, vol.4, p.4937, 2009.

M. W. Hamrick, X. Shi, W. Zhang, C. Pennington, H. Thakore et al., Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading, Bone, vol.40, pp.1544-1553, 2007.

R. Hanset and C. Michaux, On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed .1. Experimental-Data, Genet. Sel. Evol, vol.17, pp.359-368, 1985.
URL : https://hal.archives-ouvertes.fr/hal-00893652

R. Hanset, C. Michaux, C. Dessy-doize, and G. Burtonboy, In: Muscle hypertrophy of genetic origin and its use to improve beef production, Current Topics in Veterinary Medicine and Animal Science, Martinus Nijhoff, vol.16, pp.341-349, 1982.

J. J. Hill, M. V. Davies, A. A. Pearson, J. H. Wang, R. M. Hewick et al., The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum, J. Biol. Chem, vol.277, pp.40735-40741, 2002.

J. J. Hill, Y. Qiu, R. M. Hewick, and N. M. Wolfman, Regulation of myostatin in vivo by GASP-1: a novel protein with protease inhibitor and follistatin domains, Mol. Endocrinol, pp.2002-0366, 2003.

F. Jeanplong, M. Sharma, W. G. Somers, J. J. Bass, and R. Kambadur, Genomic organization and neonatal expression of the bovine myostatin gene, Mol. Cell. Biochem, vol.220, pp.31-37, 2001.

J. S. Losinski, R. L. Cornelius, S. G. Frank, G. R. Willis, G. M. Gerrard et al., Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation, Regulatory Integrative and Comparative Physiology, vol.275, pp.1265-1273, 1998.

D. Joulia, H. Bernardi, V. Garandel, F. Rabenoelina, B. Vernus et al., Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin, Exp. Cell Res, vol.286, pp.263-275, 2003.
URL : https://hal.archives-ouvertes.fr/hal-02675798

R. Kambadur, M. Sharma, T. P. Smith, and J. J. Bass, Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle, Genome Res, vol.7, pp.910-915, 1997.

R. Kambadur, A. Bishop, M. S. Salerno, S. Mccroskery, and M. Sharma, Role of myostatin in muscle growth, Muscle development of livestock animals: physiology, genetics and meat quality, pp.297-316, 2004.

T. Kerr, E. H. Roalson, and B. D. Rodgers, Phylogenetic analysis of the myostatin gene subfamily and the differential expression of a novel member in zebrafish, Evol. Dev, vol.7, pp.390-400, 2005.

H. S. Kim, L. Liang, R. G. Dean, D. B. Hausman, D. L. Hartzell et al., Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures, Biochem. Biophys. Res. Commun, vol.281, pp.902-906, 2001.

H. Kocamis, J. Richter, H. Klandorf, and J. Killefer, The ontogeny of myostatin and follistatin mRNA expression during chicken embryonic development, FASEB J, vol.13, pp.356-356, 1999.

H. Kocamis, S. Gahr, J. J. Richter, and J. Killefer, In ovo IGF-I effect on the developmental pattern of myostatin, follistatin, activin B, and TGF-beta 2 gene expression during chick embryonic development, FASEB J, vol.15, pp.756-756, 2001.

B. Langley, M. Thomas, A. Bishop, M. Sharma, S. Gilmour et al., Myostatin inhibits myoblast differentiation by down-regulating myod expression, J. Biol. Chem, vol.277, pp.49831-49840, 2002.

S. J. Lee, Regulation of muscle mass by myostatin, Ann. Rev. Cell .Dev. Biol, vol.20, pp.61-86, 2004.

S. J. Lee, Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways, PLoS ONE, vol.2, p.789, 2007.

S. J. Lee, Genetic analysis of the role of proteolysis in the activation of latent myostatin, PLoS ONE, vol.3, 1628.

S. J. Lee and A. C. Mcpherron, Regulation of myostatin activity and muscle growth, Proc. Nat. Acad. Sci, vol.98, pp.9306-9311, 2001.

J. Lin, H. B. Arnold, M. A. Della-fera, M. J. Azain, D. L. Hartzell et al., Myostatin knockout in mice increases myogenesis and decreases adipogenesis, Biochem. Biophys. Res. Commun, vol.291, pp.701-716, 2002.

A. Listrat, B. Picard, R. Jailler, H. Collignon, J. R. Peccatte et al., Grass valorisation and muscular characteristics of blonde d'Aquitaine steers, Anim. Res, vol.50, pp.105-118, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00889858

W. Liu, S. G. Thomas, S. L. Asa, N. Gonzalez-cadavid, S. Bhasin et al., Myostatin Is a Skeletal muscle target of growth hormone anabolic action, J. Clin. Endocrinol. Metabolism, vol.88, pp.5490-5496, 2003.

K. Ma, C. Mallidis, S. Bhasin, V. Mahabadi, J. Artaza et al., Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression, Am. J. Physiol. Endocrinol. Metabolism, vol.285, pp.363-371, 2003.

M. M. Matzuk, N. Lu, H. Vogel, K. Sellheyer, D. R. Roop et al., Multiple defects and perinatal death in mice deficient in follistatin, Nature, vol.374, pp.360-363, 1995.

S. Mccroskery, M. Thomas, L. Maxwell, M. Sharma, and R. Kambadur, Myostatin negatively regulates satellite cell activation and self-renewal, J. Cell Biol, vol.162, pp.1135-1147, 2003.

C. Mcfarlane, E. Plummer, M. Thomas, A. Hennebry, M. Ashby et al., Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism, J. Cell. Physiol, vol.209, pp.501-514, 2006.

C. Mcfarlane, A. Hennebry, M. Thomas, E. Plummer, N. Ling et al., Myostatin signals through Pax7 to regulate satellite cell self-renewal, Exp. Cell Res, vol.314, pp.317-329, 2008.

A. C. Mcpherron and S. J. Lee, Double muscling in cattle due to mutations in the myostatin gene, Proc. Nat. Acad. Sci, vol.94, pp.12457-12461, 1997.

A. C. Mcpherron and S. J. Lee, Suppression of body fat accumulation in myostatin-deficient mice, J. Clin. Inv, vol.109, pp.595-601, 2002.

A. C. Mcpherron, A. M. Lawler, and S. J. Lee, Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member, Nature, vol.387, pp.83-90, 1997.

L. Mendler, E. Zador, M. Ver-heyen, L. Dux, and F. Wuytack, Myostatin levels in regenerating rat muscles and in myogenic cell cultures, J. Muscle Res. Cell Motility, vol.21, pp.551-563, 2000.

L. Mendler, Z. Baka, A. Kovacs-simon, and L. Dux, Androgens negatively regulate myostatin expression in an androgen-dependent skeletal muscle, Biochem. Biophys. Res. Commun, vol.361, pp.237-242, 2007.

F. Menissier, Muscle hypertrophy of genetic origin and its use to improve beef production, Current Topics in Veterinary Medicine and Animal Science, Martinus Nijhoff, vol.16, pp.21-53, 1982.

F. Menissier, Present state of knowledge about the genetic determination of muscular hypertrophy or the double muscled trait in cattle, Current Topics in Veterinary Medicine and Animal Science, Martinus Nijhoff, vol.16, pp.387-428, 1982.
URL : https://hal.archives-ouvertes.fr/hal-02718985

F. Menissier, Advantages of using muscled sires in crossbreeding and the selection of a specialised double muscled sire line in France, Current Topics in Veterinary Medicine and Animal Science, Martinus Nijhoff, vol.16, pp.480-536, 1982.

T. Miura, Y. Kishioka, J. I. Wakamatsu, A. Hattori, A. Hennebry et al., Decorin binds myostatin and modulates its activity to muscle cells, Biochem. Biophys. Res. Commun, vol.340, pp.675-680, 2006.

M. R. Morissette, S. A. Cook, C. Buranasombati, M. A. Rosenberg, and A. Rosenzweig, Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt, Am. J. Physiol. Cell Physiol, vol.297, pp.1124-1132, 2009.

D. S. Mosher, P. Quignon, C. D. Bustamante, N. B. Sutter, C. S. Mellersh et al., A Mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs, PLoS Genetics, vol.3, p.79, 2007.

G. Nicholas, M. Thomas, B. Langley, W. Somers, K. Patel et al., Titin-cap associates with, and regulates secretion of, Myostatin. J. Cell. Physiol, vol.193, pp.120-131, 2002.

J. M. Oldham, J. A. Martyn, M. Sharma, F. Jeanplong, R. Kambadur et al., Molecular expression of myostatin and MyoD is greater in double-muscled than normal-muscled cattle fetuses, Regulatory Integrative and Comparative Physiology, vol.280, pp.1488-1493, 2001.

T. K. Østbye, O. F. Wetten, A. Tooming-klunderud, K. S. Jakobsen, A. Yafe et al., Myostatin (MSTN) gene duplications in Atlantic salmon (Salmo salar): Evidence for different selective pressure on teleost MSTN-1 and -2, Gene, vol.403, pp.159-169, 2007.

Y. M. Patel and M. D. Lane, Mitotic Clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27, J. Biol. Chem, vol.275, pp.17653-17660, 2000.

B. Philip, Z. Lu, and Y. Gao, Regulation of GDF-8 signaling by the p38 MAPK, Cell. Signalling, vol.17, pp.365-375, 2005.

B. Picard, L. Lefaucheur, C. Berri, and J. M. Duclos, Muscle fibre ontogenesis in farm animal species, Reprod. Nutr. Dev, vol.42, pp.415-431, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00900337

F. Raynaud, G. Carnac, A. Marcilhac, and Y. Benyamin, m-Calpain implication in cell cycle during muscle precursor cell activation, Exp. Cell Res, vol.298, pp.48-57, 2004.

A. Rebbapragada, H. Benchabane, J. L. Wrana, A. J. Celeste, and L. Attisano, Myostatin signals through a transforming growth factor β-Like signaling pathway to block adipogenesis, vol.23, pp.7230-7242, 2003.

S. Reisz-porszasz, S. Bhasin, J. N. Artaza, R. Shen, I. Sinha-hikim et al., Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin, Am. J. Physiol., Endocrinology and Metabolism, vol.285, pp.876-888, 2003.

P. Y. Rescan, I. Jutel, and C. Ralliere, Two myostatin genes are differentially expressed in myotomal muscles of the trout (Oncorhynchus mykiss), J. Exp. Biol, vol.204, pp.3523-3529, 2001.
URL : https://hal.archives-ouvertes.fr/hal-02674368

R. Ríos, I. Carneiro, V. M. Arce, and J. Devesa, Myostatin regulates cell survival during C2C12 Myogenesis, Biochem. Biophys. Res. Commun, vol.280, pp.561-566, 2001.

R. Ríos, I. Carneiro, V. M. Arce, and J. Devesa, Myostatin is an inhibitor of myogenic differentiation, Am. J. Physiol, vol.282, pp.993-999, 2002.

B. D. Rodgers and D. K. Garikipati, Clinical, agricultural and evolutionary biology of myostatin; a comparative review, Endocrine Rev, pp.2008-2011, 2008.

B. D. Rodgers, E. H. Roalson, G. M. Weber, S. B. Roberts, and F. W. Goetz, A proposed nomenclature consensus for the myostatin gene family, Am. J. Physiol., Endocrinol. and Metabolism, vol.292, pp.371-372, 2007.

K. Sakuma, K. Watanabe, M. Sano, I. Uramoto, and T. Totsuka, Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles, Molecular Cell Research, vol.1497, pp.77-88, 2000.

B. Salehian, V. Mahabadi, J. Bilas, W. E. Taylor, and K. Ma, The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression, Metabol. Clin. Exp, vol.55, pp.1239-1247, 2006.

M. S. Salerno, M. Thomas, D. Forbes, T. Watson, R. Kambadur et al., Molecular analysis of fiber type-specific expression of murine myostatin promoter, Am. J. Physiol, vol.287, pp.1031-1040, 2004.

A. Sazanov, D. Ewald, J. Buitkamp, and R. Fries, A molecular marker for the chicken myostatin gene (GDF8) maps to 7p11, Anim. Genet, vol.30, pp.388-389, 1999.

O. Schakman, H. Gilson, and J. P. Thissen, Mechanisms of glucocorticoid-induced myopathy, J. Endocrinol, vol.197, pp.1-10, 2008.

M. Schuelke, K. R. Wagner, L. E. Stolz, C. Hubner, T. Riebel et al., Myostatin mutation associated with gross muscle hypertrophy in a child, New Engl. J. Med, vol.350, pp.2682-2688, 2004.

M. Sharma, R. Kambadur, and B. G. Matthews,

W. G. Somers, G. P. Devlin, J. V. Conaglen, P. J. Fowke, and J. J. Bass, Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct, J. Cell. Physiol, vol.180, pp.1-9, 1999.

M. Shibata, K. Matsumoto, K. Aikawa, T. Muramoto, S. Fujimura et al., Gene expression of myostatin during development and regeneration of skeletal muscle in Japanese Black Cattle, J. Anim. Sci, vol.84, pp.2983-2989, 2006.

T. P. Smith, N. L. Lopez-corrales, S. M. Kappes, and T. S. Sonstegard, Myostatin maps to the interval containing the bovine mh locus, Mammalian Genome, vol.8, pp.742-744, 1997.

T. S. Sonstegard, G. A. Rohrer, and T. P. Smith, Myostatin maps to porcine chromosome 15 by linkage and physical analyses, Anim. Genet, vol.29, pp.19-22, 1998.

C. A. Steelman, J. C. Recknor, D. Nettleton, and J. M. Reecy, Transcriptional profiling of myostatin-knockout mice implicates Wnt signaling in postnatal skeletal muscle growth and hypertrophy, FASEB J, vol.20, pp.580-582, 2006.

G. Szabo, G. Dallmann, G. Muller, and L. Patthy,

M. Soller and L. Varga, A deletion in the myostatin gene causes the compact (Cmpt) hypermuscular mutation in mice, Mammalian Genome, vol.9, pp.671-672, 1998.

M. Thomas, B. Langley, C. Berry, M. Sharma, S. Kirk et al., Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation, J. Biol. Chem, vol.275, pp.40235-40243, 2000.

M. Thomas, B. Langley, C. Berry, M. Sharma, S. Kirk et al., Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation, J. Biol. Chem, vol.275, pp.40235-40243, 2000.

A. U. Trendelenburg, A. Meyer, and D. Rohner,

J. Boyle, S. Hatakeyama, and D. J. Glass, Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size, Am. J. Physiol, vol.296, pp.1258-1270, 2009.

K. Tsuchida, K. Y. Arai, Y. Kuramoto, N. Yamakawa, Y. Hasegawa et al., Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family, J. Biol. Chem, vol.275, pp.40788-40796, 2000.

K. R. Wagner, A. C. Mcpherron, N. Winik, and S. J. Lee, Loss of myostatin attenuates severity of muscular dystrophy in mdx mice, Ann. Neurol, vol.52, pp.832-836, 2002.

K. R. Wagner, X. Liu, X. Chang, and R. E. Allen, Muscle regeneration in the prolonged absence of myostatin, Proc. Nat. Acad. Sci. USA, vol.102, pp.2519-2524, 2005.

H. X. Wang, Q. Zhang, and D. H. Zhu, hSGT interacts with the N-terminal region of myostatin, Biochem. Biophys. Res. Commun, vol.311, pp.877-883, 2003.

J. Wegner, E. Albrecht, I. Fiedler, F. Teuscher, H. J. Papstein et al., Growth-and breed-related changes of muscle fiber characteristics in cattle, J. Anim. Sci, vol.78, pp.1485-1496, 2000.

M. Wehling, B. Y. Cai, and J. G. Tidball, Modulation of myostatin expression during modified muscle use, FASEB J, vol.14, pp.103-110, 2000.

S. L. Welle, Myostatin and muscle fiber size. Focus on Smad2 and 3 transcription factors control muscle mass in adulthood and Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size, Am. J. Physiol, vol.296, pp.1245-1247, 2009.

N. M. Wolfman, A. C. Mcpherron, W. N. Pappano, M. V. Davies, K. Song et al., Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases, Proc. Nat. Acad. Sci. USA, vol.100, pp.15842-15846, 2003.

C. Xu, G. Wu, Y. Zohar, and S. J. Du, Analysis of myostatin gene structure, expression and function in zebrafish, J. Exp. Biol, vol.206, pp.4067-4079, 2003.

K. Yamanouchi, C. Soeta, K. Naito, and H. Tojo, Expression of myostatin gene in regenerating skeletal muscle of the rat and its localization, Biochem. Biophys. Res. Commun, vol.270, pp.510-516, 2000.

W. Yang, Y. Zhang, G. Ma, X. Zhao, Y. Chen et al., Identification of gene expression modifications in myostatin-stimulated myoblasts, Biochem. Biophys. Res. Commun, vol.326, pp.660-666, 2005.

W. Yang, Y. Chen, Y. Zhang, X. Wang, N. Yang et al., Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression, Cancer Res, vol.66, pp.1320-1326, 2006.

W. Yang, Y. Zhang, Y. Li, Z. Wu, and D. Zhu, Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1, J. Biol. Chem, vol.282, pp.3799-3808, 2007.

K. E. Yarasheski, S. Bhasin, I. Sinha-hikim, J. Pak-loduca, and N. F. Gonzalez-cadavid, Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting, J. Nutr. Health Aging, vol.6, pp.343-348, 2002.

J. J. Zachwieja, S. R. Smith, I. Sinha-hikim, N. Gonzalez-cadavid, and S. Bhasin, Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration, J. Gravit. Physiol, vol.6, pp.11-15, 1999.

X. Zhu, S. Topouzis, L. F. Liang, and R. L. Stotish, Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism, Cytokine, vol.26, pp.262-272, 2004.

T. A. Zimmers, M. V. Davies, L. G. Koniaris, P. Haynes, A. F. Esquela et al., Induction of cachexia in mice by systemically administered myostatin, Science, vol.296, pp.1486-1488, 2002.