L. A. Van-meeteren and W. H. Moolenaar, Regulation and biological activities of the autotaxin-LPA axis, Prog Lipid Res, vol.46, pp.145-160, 2007.

L. T. Budnik and A. K. Mukhopadhyay, Lysophosphatidic acid-induced nuclear localization of protein kinase C? in bovine theca cells stimulated with luteinizing hormone, Biol Reprod, vol.67, pp.935-944, 2002.

K. Hinokio, S. Yamano, K. Nakagawa, M. Iraharaa, M. Kamada et al., Lysophosphatidic acid stimulates nuclear and cytoplasmic maturation of golden hamster immature oocytes in vitro via cumulus cells, Life Sci, vol.70, pp.759-767, 2002.

K. Kunikata, S. Yamano, A. Tokumura, and T. Aono, Effect of lysophosphatidic acid on the ovum transport in mouse oviducts, Life Sci, vol.65, pp.833-840, 1999.

T. Kobayashi, S. Yamano, S. Murayama, H. Ishikawa, A. Tokumura et al., Effect of lysophosphatidic acid on the preimplantation development of mouse embryos, FEBS Lett, vol.351, pp.38-40, 1994.

X. Ye, K. Hama, J. J. Contos, B. Anliker, A. Inoue et al., LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing, Nature, vol.435, pp.104-108, 2005.

A. Tokumura, E. Majima, Y. Kariya, K. Tominaga, K. Kogure et al., Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase, J Biol Chem, vol.277, pp.39436-39442, 2002.

H. Y. Lee, J. Murata, C. T. Polymeropoulos, M. H. Torres, R. Manrow et al., Stracke ML 1996 Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells, Biochem Biophys Res Commun, vol.218, pp.714-719

J. P. Pradere, E. Tarnus, S. Gres, P. Valet, and J. S. Saulnier-blache, Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase, Biochim Biophys Acta, vol.1771, pp.93-102, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00115644

A. Tokumura, Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids, Biochim Biophys Acta, vol.1582, pp.18-25, 2002.

D. Meyer-zu-heringdorf and K. H. Jakobs, Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism, Biochim Biophys Acta, vol.1768, pp.923-940, 2007.

K. Noguchi, S. Ishii, and T. Shimizu, Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family, J Biol Chem, vol.278, pp.25600-25606, 2003.

C. W. Lee, R. Rivera, S. Gardell, A. E. Dubin, and J. Chun, GPR92 as a new G12/13-and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5, J Biol Chem, vol.281, pp.23589-23597, 2006.

E. J. Van-corven, A. Groenink, K. Jalink, T. Eichholtz, and W. H. Moolenaar, , 1989.

, Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins, Cell, vol.59, pp.45-54

B. Anliker and J. Chun, Cell surface receptors in lysophospholipid signaling, Semin Cell Dev Biol, vol.15, pp.457-465, 2004.

A. H. Yang, I. Ishii, and J. Chun, In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice, Biochim Biophys Acta, vol.1582, pp.197-203, 2002.

J. J. Contos, N. Fukushima, J. A. Weiner, D. Kaushal, and J. Chun, Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior, Proc Natl Acad Sci, vol.97, pp.13384-13389, 2000.

J. J. Contos, I. Ishii, N. Fukushima, M. A. Kingsbury, X. Ye et al., Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/ Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2), Mol Cell Biol, vol.22, pp.6921-6929, 2002.

H. Song, H. Lim, B. C. Paria, H. Matsumoto, L. L. Swift et al., Cytosolic phospholipase A2? is crucial [correction of A2? deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development, Development, vol.129, pp.2879-2889, 2002.

H. Lim, B. C. Paria, S. K. Das, J. E. Dinchuk, R. Langenbach et al., Multiple female reproductive failures in cyclooxygenase 2-deficient mice, Cell, vol.91, pp.197-208, 1997.

T. E. Spencer, G. A. Johnson, F. W. Bazer, and R. C. Burghardt, Implantation mechanisms: insights from the sheep, Reproduction, vol.128, pp.657-668, 2004.

M. Guillomot, J. E. Flechon, and S. Wintenberger-torres, Conceptus attachment in the ewe: an ultrastructural study, vol.2, pp.169-182, 1981.

K. Kaminska, M. Wasielak, I. Bogacka, M. Blitek, and M. Bogacki, Quantitative expression of lysophosphatidic acid receptor 3 gene in porcine endometrium during the periimplantation period and estrous cycle, Prostaglandins Other Lipid Mediat, vol.85, pp.26-32, 2008.

H. Seo, M. Kim, Y. Choi, C. K. Lee, and H. Ka, Analysis of lysophosphatidic acid receptor and lysophosphatidic acid-induced endometrial PTGS2 expression in the porcine uterus, Endocrinology, vol.149, pp.6166-6175, 2008.

G. Charpigny, P. Reinaud, J. P. Tamby, C. Creminon, and M. Guillomot, Cyclooxygenase-2 unlike cyclooxygenase-1 is highly expressed in ovine embryos during the implantation period, Biol Reprod, vol.57, pp.1032-1040, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02693448

G. Charpigny, P. Reinaud, J. P. Tamby, C. Creminon, J. Martal et al., Expression of cyclooxygenase-1 and -2 in ovine endometrium during the estrous cycle and early pregnancy, Endocrinology, vol.138, pp.2163-2171, 1997.
URL : https://hal.archives-ouvertes.fr/hal-02691616

J. S. Saulnier-blache, A. Girard, M. F. Simon, M. Lafontan, and P. Valet, A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification, J Lipid Res, vol.41, pp.1947-1951, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00110161

E. Billon-denis, Z. Tanfin, and P. Robin, Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin, J Lipid Res, vol.49, pp.295-307, 2008.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, vol.162, pp.156-159, 1987.

L. Cammas, P. Reinaud, N. Bordas, O. Dubois, G. Germain et al., Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period, vol.131, pp.917-927, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02658925

G. Charpigny, P. Reinaud, C. Creminon, and J. P. Tamby, Correlation of increased concentration of ovine endometrial cyclooxygenase 2 with the increase in PGE2 and PGD2 in the late luteal phase, J Reprod Fertil, vol.117, pp.315-324, 1999.
URL : https://hal.archives-ouvertes.fr/hal-02693721

A. Tokumura, Y. Kanaya, M. Miyake, S. Yamano, M. Irahara et al., Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy, Biol Reprod, vol.67, pp.1386-1392, 2002.

Y. Menezo, Sécrétions utérines associées à la phase périovulatoire et à la vie libre des blastocystes, Utérus et fécondité, pp.3-16, 1981.

A. Enders and S. Schlafke, A morphological analysis of the early implantation stages in the rat, Am J Anat, vol.120, pp.185-226, 1967.

J. Aoki, Mechanisms of lysophosphatidic acid production, Semin Cell Dev Biol, vol.15, pp.477-489, 2004.

L. A. Van-meeteren, P. Ruurs, C. Stortelers, P. Bouwman, M. A. Van-rooijen et al., Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development, Mol Cell Biol, vol.26, pp.5015-5022, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00110104

M. Tanaka, S. Okudaira, Y. Kishi, R. Ohkawa, S. Iseki et al., Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid, J Biol Chem, vol.281, pp.25822-25830, 2006.

T. R. Hansen, K. Imakawa, H. G. Polites, K. R. Marotti, R. V. Anthony et al., Interferon RNA of embryonic origin is expressed transiently during early pregnancy in the ewe, J Biol Chem, vol.263, pp.12801-12804, 1988.

M. Kazemi, P. V. Malathy, D. H. Keisler, and R. M. Roberts, Ovine trophoblast protein-1 and bovine trophoblast protein-1 are present as specific components of uterine flushings of pregnant ewes and cows, Biol Reprod, vol.39, pp.457-463, 1988.

K. Hama, J. Aoki, K. Bandoh, A. Inoue, T. Endo et al., Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus, Life Sci, vol.79, pp.1736-1740, 2006.

W. V. Ingman and R. L. Jones, Cytokine knockouts in reproduction: the use of gene ablation to dissect roles of cytokines in reproductive biology, Hum Reprod Update, vol.14, pp.179-192, 2008.

G. Chaouat, S. Dubanchet, and N. Ledee, Cytokines: important for implantation?, J Assist Reprod Genet, vol.24, pp.491-505, 2007.

C. Zhao, M. J. Fernandes, G. D. Prestwich, M. Turgeon, D. Battista et al., Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis, Mol Pharmacol, vol.73, pp.587-600, 2008.

A. Tokumura, Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators, J Cell Biochem, vol.92, pp.869-881, 2004.

Y. J. Xu, S. S. Rathi, D. C. Chapman, A. S. Arneja, and N. S. Dhalla, Mechanisms of lysophosphatidic acid-induced DNA synthesis in vascular smooth muscle cells, J Cardiovasc Pharmacol, vol.41, pp.381-387, 2003.

F. Gobeil, S. G. Bernier, A. Vazquez-tello, S. Brault, M. H. Beauchamp et al., Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1, J Biol Chem, vol.278, pp.38875-38883, 2003.

C. M. Waters, B. Saatian, N. A. Moughal, Y. Zhao, G. Tigyi et al., Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells, Biochem J, vol.398, pp.55-62, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00478521

N. A. Moughal, C. Waters, B. Sambi, S. Pyne, and N. J. Pyne, Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells, Cell Signal, vol.16, pp.127-136, 2004.

N. Kumagai, N. Morii, K. Fujisawa, T. Yoshimasa, K. Nakao et al., Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells, FEBS Lett, vol.329, pp.273-276, 1993.

P. L. Hordijk, I. Verlaan, E. J. Van-corven, and W. H. Moolenaar, Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts. Evidence that phosphorylation of MAP kinase is mediated by the Gi-p21ras pathway, J Biol Chem, vol.269, pp.645-651, 1994.

I. Ishii, J. J. Contos, N. Fukushima, and J. Chun, Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system, Mol Pharmacol, vol.58, pp.895-902, 2000.

L. Blomberg, K. Hashizume, and C. Viebahn, Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation, Reproduction, vol.135, pp.181-195, 2008.

M. K. Saba-el-leil, F. D. Vella, B. Vernay, L. Voisin, L. Chen et al., An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development, EMBO Rep, vol.4, pp.964-968, 2003.

G. Daoud, M. Amyot, E. Rassart, A. Masse, L. Simoneau et al., ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta, J Physiol, vol.566, pp.409-423, 2005.

Z. Liu and D. R. Armant, Lysophosphatidic acid regulates murine blastocyst development by transactivation of receptors for heparin-binding EGF-like growth factor, Exp Cell Res, vol.296, pp.317-326, 2004.

S. Shiokawa, K. Sakai, Y. Akimoto, N. Suzuki, H. Hanashi et al., Function of the small guanosine triphosphate-binding protein RhoA in the process of implantation, J Clin Endocrinol Metab, vol.85, pp.4742-4749, 2000.

H. Tamada, C. Higashiyama, H. Takano, N. Kawate, T. Inaba et al., The effects of heparin-binding epidermal growth factor-like growth factor on preimplantation-embryo development and implantation in the rat, Life Sci, vol.64, pp.1967-1973, 1999.

T. Klonisch, P. Wolf, S. Hombach-klonisch, S. Vogt, A. Kuechenhoff et al., Epidermal growth factor-like ligands and erbB genes in the peri-implantation rabbit uterus and blastocyst, Biol Reprod, vol.64, pp.1835-1844, 2001.

X. Wang, H. Wang, H. Matsumoto, S. K. Roy, S. K. Das et al., Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster, Development, vol.129, pp.4125-4134, 2002.

M. M. Parast, S. Aeder, and A. E. Sutherland, Trophoblast giant-cell differentiation involves changes in cytoskeleton and cell motility, Dev Biol, vol.230, pp.43-60, 2001.

V. P. Sah, T. M. Seasholtz, S. A. Sagi, and J. H. Brown, The role of Rho in G protein-coupled receptor signal transduction, Annu Rev Pharmacol Toxicol, vol.40, pp.459-489, 2000.

W. H. Moolenaar, Development of our current understanding of bioactive lysophospholipids, Ann NY Acad Sci, vol.905, pp.1-10, 2000.

S. An, T. Bleu, O. G. Hallmark, and E. J. Goetzl, Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid, J Biol Chem, vol.273, pp.7906-7910, 1998.

R. M. Kramer and J. D. Sharp, Structure, function and regulation of Ca2?-sensitive cytosolic phospholipase A2 (cPLA2), FEBS Lett, vol.410, pp.49-53, 1997.

F. D'aquilio, M. Procaccini, V. Izzi, V. Chiurchiu, V. Giambra et al., Activatory properties of lysophosphatidic acid on human THP-1 cells, Inflammation, vol.30, pp.167-177, 2007.

C. N. Inoue, H. G. Forster, and M. Epstein, Effects of lysophosphatidic acid, a novel lipid mediator, on cytosolic Ca2? and contractility in cultured rat mesangial cells, Circ Res, vol.77, pp.888-896, 1995.

J. Symowicz, B. P. Adley, M. M. Woo, N. Auersperg, L. G. Hudson et al., , 2005.

, Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells, Cancer Res, vol.65, pp.2234-2242

C. O. Reiser, T. Lanz, F. Hofmann, G. Hofer, H. D. Rupprecht et al., Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins, Biochem J, vol.330, pp.1107-1114, 1998.

D. He, V. Natarajan, R. Stern, I. A. Gorshkova, J. Solway et al., Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBP? in human bronchial epithelial cells, Biochem J, vol.412, pp.153-162, 2008.

R. A. Oyesanya, Z. P. Lee, J. Wu, J. Chen, Y. Song et al., Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells, FASEB J, vol.22, pp.2639-2651, 2008.

M. Gurevich, E. Harel-markowitz, S. Marcus, L. S. Shore, and M. Shemesh, Prostaglandin production by the oocyte cumulus complex around the time of fertilization and the effect of prostaglandin E on the development of the early bovine embryo, Reprod Fertil Dev, vol.5, pp.281-283, 1993.

F. Nuttinck, P. Reinaud, H. Tricoire, C. Vigneron, N. Peynot et al., Cyclooxygenase-2 is expressed by cumulus cells during oocyte maturation in cattle, Mol Reprod Dev, vol.61, pp.93-101, 2002.
URL : https://hal.archives-ouvertes.fr/hal-02676043

B. L. Sayre and G. S. Lewis, Arachidonic acid metabolism during early development of ovine embryos: a possible relationship to shedding of the zona pellucida, Prostaglandins, vol.45, pp.557-569, 1993.

G. S. Lewis, W. W. Thatcher, and F. W. Bazer, Curl JS 1982 Metabolism of arachidonic acid in vitro by bovine blastocysts and endometrium, Biol Reprod, vol.27, pp.431-439

D. H. Hwang, S. H. Pool, R. W. Rorie, M. Boudreau, and R. A. Godke, Transitional changes in arachidonic acid metabolism by bovine embryos at different developmental stages, Prostaglandins, vol.35, pp.387-402, 1988.

F. N. Scenna, J. L. Edwards, N. R. Rohrbach, M. E. Hockett, A. M. Saxton et al., Detrimental effects of prostaglandin F2? on preimplantation bovine embryos, Prostaglandins Other Lipid Mediat, vol.73, pp.215-226, 2004.

C. Nicola, A. Chirpac, P. K. Lala, and C. Chakraborty, Roles of Rho guanosine 5?-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast, Endocrinology, vol.149, pp.1243-1251, 2008.

C. Biondi, M. E. Ferretti, B. Pavan, L. Lunghi, B. Gravina et al., Prostaglandin E2 inhibits proliferation and migration of HTR-8/SVneo cells, a human trophoblast-derived cell line, Placenta, vol.27, pp.592-601, 2006.

L. E. Casida, C. O. Woody, and A. L. Pope, Inequality in function of the right and left ovaries and uterine horns of the ewe, J Anim Sci, vol.25, pp.1169-1171, 1966.

K. P. Nephew, K. E. Mcclure, and W. F. Pope, Embryonic migration relative to maternal recognition of pregnancy in sheep, J Anim Sci, vol.67, pp.999-1005, 1989.