The hypothesis that grey mould incidence would be positively correlated to grapevine canopy development was confirmed over a period of 3 years (2004–2006) on Aranel cultivar in an experimental vineyard near Montpellier, south France. Different levels of vine growth were generated by implementing three management schemes: (i) perennial cover crop, (ii) chemical weed control and (iii) irrigation and fertilisation. Grey mould incidence was assessed at harvest, together with various sets of variables linked with canopy microclimate, shoot vigour, vine capacity, cluster architecture, yield components and fruit composition. Significant positive correlations were observed between disease incidence and key variables of shoot vigour and vine capacity: total leaf number, leaf dry matter, leaf layer number, leaf area per metre of row, pruning mass and nitrogen accumulation. In 2004, Botrytis cinerea developed in all experimental plots because climatic and microclimatic conditions were conducive to grey mould. The climatic and microclimatic variables that significantly favoured grey mould development were: precipitation, duration of relative humidity >90% in the canopy and low potential evapotranspiration. However, in 2005 and 2006, under dry summer conditions, disease developed only in the most vigorous vines, which were both irrigated and fertilised. These vines showed a very high canopy growth, very compact clusters and a delayed fruit maturity. This evidenced that unfavourable climatic conditions for the disease development can be counterbalanced by conditions of high vine growth and associated canopy and cluster features.