Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met with fi eld isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.

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Sciences du Vivant [q-bio]

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2008_Béringue_Emerging Infectious Diseases_1 (301.38 Ko)

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Soumis le : dimanche 31 mai 2020-09:52:36

Dernière modification le : vendredi 22 novembre 2024-13:47:09

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hal-02667014 , version 1 (31-05-2020)

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HAL Id : hal-02667014 , version 1
DOI : 10.3201/eid1412.080941
PRODINRA : 145715
PUBMED : 19046515
WOS : 000262911800012

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Vincent Béringue, Laetitia Herzog, Fabienne Reine, Annick Le Dur, Cristina Casalone, et al.. Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein. Emerging Infectious Diseases, 2008, 14 (12), pp.1898-1901. ⟨10.3201/eid1412.080941⟩. ⟨hal-02667014⟩

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