Breast cancer cell response to genistein is conditioned by BRCA1 mutations - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2009

Breast cancer cell response to genistein is conditioned by BRCA1 mutations

Résumé

Soy phytoestrogens, among which genistein, seem to protect from breast cancer development. In order to study the role of the breast tumour suppressor BRCA1 in response to genistein, we used a new breast cancer cell model: the SUM1315MO2 cell line carrying the 185delAG BRCA1 mutation, which we stably transfected with a plasmid encoding wild-type BRCA1. We showed that growth of BRCA1 mutant cells was strongly inhibited by genistein whereas it only had a weak effect in cells expressing wild-type BRCA1 protein. BRCA1 mutant cells hypersensitivity could be linked to higher expression of ER beta gene, which suggests that genistein may be an efficient inhibitor of cancer development in BRCA1 mutant breast cancer cells.
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hal-02667386 , version 1 (31-05-2020)

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Maud Privat, Corinne Aubel, Stéphanie Arnould, Yves Communal, Marc M. Ferrara, et al.. Breast cancer cell response to genistein is conditioned by BRCA1 mutations. Biochemical and Biophysical Research Communications, 2009, 379 (3), pp.785-789. ⟨10.1016/j.bbrc.2008.12.151⟩. ⟨hal-02667386⟩
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