Growth arrest and cell death induced by the dietary anticarcinogen sulforaphane in human renal cancer cells are maintained after it was conjugated to glutathione - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue NAFAS Science Année : 2005

Growth arrest and cell death induced by the dietary anticarcinogen sulforaphane in human renal cancer cells are maintained after it was conjugated to glutathione

Patrick Rouimi
Connectez-vous pour contacter l'auteur
Thierry Fricaux
  • Fonction : Auteur
  • PersonId : 1206678
Nicole Gasc
  • Fonction : Auteur
Emilie Amillastre
  • Fonction : Auteur

Résumé

Various epidemiological studies have revealed an inverse association between renal cancer and consumption of cruciferous vegetables. Sulforaphane, a natural microconstituant from broccoli, has been shown to exert potent anti-tumoral properties in vitro as well as in vivo against colon and mammary chemically-induced tumors. Here, we show in human renal carcinoma cells ACHN cells, that conjugation of sulforaphane to glutathione, a process mainly responsible for its accumulation invarious cells, did not change the properties of this isothiocyanate (i.e. cell death, cell cycle arrest inthe S-phase and cyclin A and B1 induced-expression). This result constitutes a good support to possible protective properties against renal cancer described for cruciferous vegetables. Second, our finding seems to be in agreement with the previously described activation of compounds by conjugation to GSH. This may have important implications especially in explaining the effects of rapidly conjugated compounds on tissues and organs distant from the original site of exposure and/or conjugation.
Fichier principal
Vignette du fichier
rouimi_nafas2_2005_1.pdf (150.83 Ko) Télécharger le fichier
rouimi_nafas2_2005_2.doc (68 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02676025 , version 1 (31-05-2020)

Licence

Paternité

Identifiants

  • HAL Id : hal-02676025 , version 1
  • PRODINRA : 483262

Citer

Patrick Rouimi, Thierry Fricaux, Nicole Gasc, Emilie Amillastre. Growth arrest and cell death induced by the dietary anticarcinogen sulforaphane in human renal cancer cells are maintained after it was conjugated to glutathione. NAFAS Science, 2005, 3, pp.87-95. ⟨hal-02676025⟩
7 Consultations
11 Téléchargements

Partager

Gmail Facebook X LinkedIn More