Skip to Main content Skip to Navigation
Journal articles

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Abstract : A prominent response during the Drosophila host defence is the induction of proteolytic cascades, some of which lead to localized melanization of pathogen surfaces, while others activate one of the major players in the systemic antimicrobial response, the Toll pathway. Despite the fact that gain-of-function mutations in the Toll receptor gene result in melanization, a clear link between Toll activation and the melanization reaction has not been firmly established. Here, we present evidence for the coordination of hemolymph-borne melanization with activation of the Toll pathway in the Drosophila host defence. The melanization reaction requires Toll pathway activation and depends on the removal of the Drosophila serine protease inhibitor Serpin27A. Flies deficient for this serpin exhibit spontaneous melanization in larvae and adults. Microbial challenge induces its removal from the hemolymph through Toll-dependent transcription of an acute phase immune reaction component.
Document type :
Journal articles
Complete list of metadata
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Sunday, May 31, 2020 - 9:52:45 PM
Last modification on : Tuesday, February 2, 2021 - 6:08:02 PM

Links full text




Petros Ligoxygakis, Nadège Pelte, Chuanyi Ji, Vincent Leclerc, Bernard Duvic, et al.. A serpin mutant links Toll activation to melanization in the host defence of Drosophila.. EMBO Journal, EMBO Press, 2002, 21 (23), pp.6330-6337. ⟨10.1093/emboj/cdf661⟩. ⟨hal-02679963⟩



Record views