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The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a mediterranean-type diet or a low-fat diet

Abstract : Background: Epidemiologic studies link Mediterranean-type diets to a low incidence of cardiovascular disease; however, few dietary intervention studies have been undertaken, especially in primary prevention. Objectives: In the Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms (Medi-RIVAGE) study, the effects of a mediterranean-type diet (Med group) or a low-fat diet (low-fat group) on risk factors were evaluated in 212 volunteers (men and women) with moderate risk factors for cardiovascular disease. Design: After the 3-mo dietary intervention, changes in many risk factors were evaluated. Dietary questionnaires and plasma nutritional markers were used to test compliance. Results: Although the dietary goals were only partially reached, changes in dietary habits were observed in both groups (n=169): protein, carbohydrate, and fiber intakes increased and fat quality (decreased saturated fat and increased monounsaturated or polyunsaturated fat) improved. BMI, total and triacylglycerol-rich lipoprotein (TRL) cholesterol, triacylglycerols, TRL triacylglycerols, apolipoproteins A-I and B, insulinemia, glycemia, and the homeostasis model assessment score were significantly lower after 3 mo. The reductions in total cholesterol, triacylglycerols, and insulinemia remained significant after adjustment for BMI. There was a trend for a diet-by-time interaction for LDL cholesterol (P= 0.09). Our data predicted a 9% reduction in cardiovascular disease risk with the low-fat diet and a 15% reduction with this particular Mediterranean diet. Conclusion: After a 3-mo intervention, both diets significantly reduced cardiovascular disease risk factors to an overall comparable extent
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https://hal.inrae.fr/hal-02680529
Déposant : Migration Prodinra <>
Soumis le : dimanche 31 mai 2020 - 22:25:27
Dernière modification le : vendredi 17 juillet 2020 - 15:46:26

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  • HAL Id : hal-02680529, version 1
  • PRODINRA : 24098

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Stéphanie Vincent-Baudry, Catherine Defoort, Mariette Gerber, Marie-Christine Bernard, Pierre Verger, et al.. The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a mediterranean-type diet or a low-fat diet. American Journal of Clinical Nutrition, American Society for Nutrition, 2005, 82 (5), pp.964-971. ⟨hal-02680529⟩

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