Conservation of the MHC-like region throughout evolution - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Immunogenetics Année : 2003

Conservation of the MHC-like region throughout evolution

Résumé

Identification of conserved regions between the genomes of distant species is a crucial step in the reconstruction of the genomic organization of their last common ancestor. Here we confirm for the first time with robust evidence, the existence of a region of conserved synteny between the human genome and the Drosophila genome. This evolutionarily conserved synteny involves the human MHC and paralogous regions, and we identified 19 conserved genes between these two species in a Drosophila genomic region of less than 2 Mb. The statistical analysis of the distribution of these 19 genes between the Drosophila and human genomes shows that it cannot be explained by chance. Our study constitutes a first step towards the reconstruction of the genome of Urbilateria (the ancestor of all bilaterian) and allows for a better understanding of the evolutionary history of our genome as well as other metazoan genomes.

Dates et versions

hal-02681710 , version 1 (31-05-2020)

Identifiants

Citer

Etienne Danchin, Laurent Abi-Rached, André Gilles, Pierre Pontarotti. Conservation of the MHC-like region throughout evolution. Immunogenetics, 2003, 55 (3), pp.141-148. ⟨10.1007/s00251-003-0562-0⟩. ⟨hal-02681710⟩

Collections

UNIV-AMU INRAE
11 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More