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Mice immunization with live lactococci displaying a surface anchored HPV-16 E7 oncoprotein. Naima G Cortes-Perez f37fba46ac061ba01e33098d8f306288 inrae.fr naima-cortes-perez 737077 16763-737077 https://orcid.org/0000-0003-4189-7304 https://www.idref.fr/253129990 Luis Bermudez Humaran e007240422a6d4eff9ba0d722e8a34f8 jouy.inrae.fr luis-bermudez 1169420 844133-1169420 https://orcid.org/0000-0001-7525-3131 https://scholar.google.fr/citations?user=nT5K2v4AAAAJ Yves Le Loir ef209ee7299fc9f3ca5ab5f7c1ed6744 inrae.fr yves-le-loir 743793 2523686-743793 https://orcid.org/0000-0002-0355-1065 https://www.idref.fr/077040465 Cristina Rodríguez-Padilla 1713505-0 Alexandra A. Gruss 834373-0 Odila Saucedo-Cardenas 1920597-0 Philippe P. Langella 834307-0 Roberto Montes-De-Oca-Luna 1923827-0 Migration ProdInra 9e5ed7d56b52b3d4383123b1ffb42236 inrae.fr 2020-06-01 01:12:55 2026-04-22 03:13:17 2020-06-01 01:12:55 2003 publisher version Scientists contributor Migration ProdInra 9e5ed7d56b52b3d4383123b1ffb42236 inrae.fr CCSD hal-02682491 https://hal.inrae.fr/hal-02682491 cortesperez:hal-02682491 FEMS Microbiology Letters, 2003, 229, pp.37-42. <a target="_blank" href="https://dx.doi.org/10.1016/S0378-1097(03)00778-X">⟨10.1016/S0378-1097(03)00778-X⟩</a> FEMS Microbiology Letters, 2003, 229, pp.37-42. ⟨10.1016/S0378-1097(03)00778-X⟩ INRA - Institut national de la recherche agronomique l'unam - université nantes angers le mans Archive ouverte en agrobiosciences Institut National de Recherche en Agriculture, Alimentation et Environnement Science et technologie du lait et l'oeuf Institut Agro International No Yes Mice immunization with live lactococci displaying a surface anchored HPV-16 E7 oncoprotein. Naima G Cortes-Perez f37fba46ac061ba01e33098d8f306288 inrae.fr naima-cortes-perez 737077 16763-737077 https://orcid.org/0000-0003-4189-7304 https://www.idref.fr/253129990 Luis Bermudez Humaran e007240422a6d4eff9ba0d722e8a34f8 jouy.inrae.fr luis-bermudez 1169420 844133-1169420 https://orcid.org/0000-0001-7525-3131 https://scholar.google.fr/citations?user=nT5K2v4AAAAJ Yves Le Loir ef209ee7299fc9f3ca5ab5f7c1ed6744 inrae.fr yves-le-loir 743793 2523686-743793 https://orcid.org/0000-0002-0355-1065 https://www.idref.fr/077040465 Cristina Rodríguez-Padilla 1713505-0 Alexandra A. Gruss 834373-0 Odila Saucedo-Cardenas 1920597-0 Philippe P. Langella 834307-0 Roberto Montes-De-Oca-Luna 1923827-0 13330 0378-1097 1574-6968 FEMS Microbiology Letters Wiley-Blackwell 229 37-42 2003 10.1016/S0378-1097(03)00778-X 258212 14659540 English papillomavirus oncoprotéine immunogénétique vaccin cancer lactococcus lactis Life Sciences [q-bio]/Human health and pathology Life Sciences [q-bio]/Microbiology and Parasitology papillomavirus santé humaine expression des gènes immunité immunogénétique oncoprotéine réponse immunitaire vaccin cancer lactococcus lactis Journal articles Journal articles Journal articles

E7 oncoprotein of human papillomavirus-16 (HPV-16) is constitutively produced in cervical cancer (CxCa) and is a good candidate for the design of therapeutic vaccines. In this work, the nisin-controlled expression system was used to display the E7 protein at the cell surface of the food-grade Gram-positive bacterium Lactococcus lactis. An efficient cell wall anchoring of E7 was obtained. Intranasal administration of these recombinant lactococci in mice induced an HPV-16 E7-specific immune response. This is the first report of E7 cell wall anchoring in L. lactis and represents one more step towards the use of live food-grade bacteria to fight against CxCa.

031784569 https://ror.org/01fh86n78 Universidad Autonoma de Nuevo Leon [Mexique] UANL 1826

Pedro de Alba s/n, San Nicolás de Los Garza, Nuevo León

http://www.uanl.mx/ https://ror.org/01x3gbx83 Institut National de la Recherche Agronomique INRA 1946-05-18 2019-12-31

http://www.inra.fr Bactéries Lactiques et Pathogènes Opportunistes UBLO 2019-12-31

F-78350 Jouy-en-Josas

Science et Technologie du Lait et de l'Oeuf STLO 2019-12-31

65, rue de Saint Brieuc 35042 Rennes

Centro de Investigaciones Biomédicas

Santiago

Universitad Autonoma de Nuevo Leon

AGROCAMPUS OUEST 2008-01-01 2019-12-31

Institut Supérieur des Sciences Agronomiques, Agroalimentaires, Horticoles et du Paysage - 65, rue de St Brieuc - CS 84215 - 35042 Rennes cedex

http://www.agrocampus-ouest.fr/ 228916135 000000012156804X https://ror.org/01qq57711 Universidad Andrés Bello [Santiago] UNAB 1988-01-01

República 239 Santiago CHILE

https://www.unab.cl/en/ Fondecyt 3130762

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