TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue Annals of the New York Academy of Sciences Année : 2005

TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.

Olivier Meurette
Laurence Huc
Dominique Lagadic-Gossmann

Résumé

How tumor microenvironment, more specifically low extracellular pH (6.5), alters cell response to TNF-related apoptosis-inducing ligand (TRAIL)-based cancer therapy has yet to be determined. The aim of the current work was to test the effect of acidic extracellular pH on TRAIL-induced cell death in human HT29 colon carcinoma and HepG2 hepatocarcinoma cell lines as well as in human primary hepatocytes. We found an increase in TRAIL sensitivity at low extracellular pH, which is partially inhibited by Bcl-2 expression in HT29 cells. At low extracellular pH, TRAIL induced a new form of cell death, sharing necrotic and apoptotic features in tumor cells. By contrast, human primary hepatocytes were resistant to TRAIL-induced cell death even at acidic extracellular pH.
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Dates et versions

hal-02683522 , version 1 (01-06-2020)

Identifiants

Citer

Olivier Meurette, Laurence Huc, Amelie Rebillard, Gwénaelle Le Moigne, Dominique Lagadic-Gossmann, et al.. TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.. Annals of the New York Academy of Sciences, 2005, 1056, pp.379-87. ⟨10.1196/annals.1352.018⟩. ⟨hal-02683522⟩

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