HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Genome of the rainbow trout (Oncorhynchus mykiss) encodes two distinct muscle regulatory factors with homology to MyoD

Abstract : Previously we identified a trout myogenic factor related to MyoD. We now present a cDNA encoding a novel trout myogenic factor (TMyoD2) expressed in embryonic muscle. Nucleotide analysis and amino acid comparison showed that this cDNA encodes a MyoD-like protein of 275 amino acids that is distinct but related to TMyoD with 78% identity over the entire length. The protein sequence conservation between TMyoD2 and TMyoD was calculated to be 90% within the basic/ helix-loop-helix domain that is involved in DNA binding and heterooligomerisation. At the nucleotide level, comparison of TMyoD with TMyoD2 reveals that the translated regions are flanked by highly divergent 3' and 5' ends. The substantial differences observed at translated and especially untranslated regions strongly suggest that TMyoD and TMyoD2 mRNA originate from different loci. The TMyoD and TMyoD2 mRNA are likely transcribed from two distinct genes which were duplicated during the tetraploidization of the salmonid genome.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02686395
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Monday, June 1, 2020 - 4:49:00 AM
Last modification on : Tuesday, April 26, 2022 - 11:32:08 AM

Identifiers

Collections

Citation

Pierre-Yves Rescan, Laurent Gauvry. Genome of the rainbow trout (Oncorhynchus mykiss) encodes two distinct muscle regulatory factors with homology to MyoD. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, Elsevier, 1996, 113B (4), pp.711-715. ⟨10.1016/0305-0491(95)02087-X⟩. ⟨hal-02686395⟩

Share

Metrics

Record views

5