Skip to Main content Skip to Navigation
Journal articles

Sub-chronic cold stress reduces 5-HT1A receptor responsiveness in the old but not in the young rat.

Abstract : The inhibitory effect of the prototypical 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propyl amino)tetraline (8-OH-DPAT) on forskolin-stimulated adenylyl cyclase activity, has been examined as an index of the functional activity of 5-HT1A receptors in the hippocampus of young (3 months) and old (18 months) rats exposed during 24 h or 5 days to cold. In both young and old rats exposed to cold stress during 24 h, there was a reduction in the potency (EC50) and/or the maximal inhibitory effect (Emax) of 8-OH-DPAT in reducing forskolin-induced cAMP accumulation. The properties of the hippocampal 5-HT1A sites labelled by [3H]8-OH-DPAT were not affected by these stressful conditions. Moreover, while the sensitivity of 5-HT1A receptors to 8-OH-DPAT in young rats returned to control values after 5 days of cold exposure, old rats still exhibited a significant desensitization of 5-HT1A receptors as compared to naive animals. These results point out the capacity of young but not of old rats to adapt to the aversive effects of a subchronic stressor.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02696759
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Monday, June 1, 2020 - 10:59:59 AM
Last modification on : Tuesday, October 19, 2021 - 10:28:29 PM

Links full text

Identifiers

Collections

Citation

Raul Manhães de Castro, Francisco Bolaños-Jiménez, Laure Seguin, Hala Sarhan, Kathy Drieu, et al.. Sub-chronic cold stress reduces 5-HT1A receptor responsiveness in the old but not in the young rat.. Neuroscience Letters, Elsevier, 1996, 203 (1), pp.21-24. ⟨10.1016/0304-3940(95)12253-2⟩. ⟨hal-02696759⟩

Share

Metrics

Record views

19