Activation of gene transcription by tilapia prolactin variants tiPRL188 and tiPRL177 - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 1998

Activation of gene transcription by tilapia prolactin variants tiPRL188 and tiPRL177

Résumé

In the tilapia species Oreochromis niloticus, the pituitary releases two forms of prolactins (tiPRL(188) and tiPRL(177)) The binding parameters and the activation of tiPRL-induced JAK2/Stat5 signalling pathway were analysed using a mammalian cell line transiently transfected with the tiPRL receptor (tiPRLR). Our data indicate that the tiPRLR is able to mediate transcriptional activation of the PRL responsive element, At nanomolar concentrations, tiPRL(188) activates gene transcription whereas at micromolar concentrations it inhibits luciferase transcription from the lactogenic responsive element. This is consistent with a model of receptor dimerisation, In contrast, the activation by tiPRL177 was only reached at high (mu M) concentrations. The transcriptional activities induced by tiPRL(177) and tiPRL(188) are discussed in the context of the physiology of these hormones.
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Dates et versions

hal-02696806 , version 1 (01-06-2020)

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Frédéric Sohm, Alain Pezet, Olivier Sandra, Patrick Prunet, Amaury de Luze, et al.. Activation of gene transcription by tilapia prolactin variants tiPRL188 and tiPRL177. FEBS Letters, 1998, 438 (1-2), pp.119-123. ⟨10.1016/S0014-5793(98)01285-X⟩. ⟨hal-02696806⟩

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