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Effects of human insulin-like growth factor-1 on the release of growth hormone by rainbow trout (Oncorhynchus mykiss) pituitary cells

Abstract : A recombinant human IGF-I (rhIGF-I) was applied to primary cultures of rainbow trout pituitary cells. In wells containing 3 x 10(4) and 6 x 10(4) cells/well, rhIGF-I inhibited basal GH release both in short (6 h) and long (12 and 24 h) exposures. The decline in GH release was dose-dependent over the range of 0.01 and 100 mM. The combination of rhIGF-I and low concentrations of synthetic somatostatin 14 (SRIF) enhanced the inhibitory effect of rhIGF-I in an additive manner. Any appreciable effect of rhIGF-I on PRL release was not evidenced. To our knowledge, this report demonstrates for the first time the participation of IGFs on the inhibitory component of fish GH regulation.
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J. Perez-Sanchez, Claudine Weil, Pierre-Yves Le Bail. Effects of human insulin-like growth factor-1 on the release of growth hormone by rainbow trout (Oncorhynchus mykiss) pituitary cells. Journal of Experimental Zoology, Wiley, 1992, 262, pp.287-290. ⟨10.1002/jez.1402620308⟩. ⟨hal-02713574⟩

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