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Poster communications

Stimulating SNpr – motor thalamus pathway in a Parkinsonian rat model modulates forelimb movement

Abstract : Degeneration of midbrain dopaminergic neurons in Parkinson’s disease (PD) causes severe movement deficits and altered neuronal activity in basal ganglia networks. Basal ganglia output is sent to motor thalamus nuclei, which innervate cortical motor areas that control voluntary movements. However, the consequences of dysfunctional basal ganglia activity on movements and motor thalamus activity are unclear. Here, we optogenetically stimulated basal ganglia output (substantia nigra pars reticulata, SNpr) to ventroanterior (VA) motor thalamus in sham and hemiparkinsonian rats (6-OHDA lesion of medial forebrain bundle) and assessed the impact on reaching performance and VA neuron activity. Stimulating SNpr axons in 6-OHDA lesioned rats with SNpr activity previously recorded from a walking sham rat significantly increased the number of reaches executed by the affected paw. The same number of stimuli applied tonically at 9 Hz significantly impaired reaching in the lesioned group, but did not affect sham rats. Mean VA neurons firing rate was higher in 6-OHDA lesioned than sham rats. SNpr stimulation modulated VA firing rate; inhibiting 13% and exciting 53% of VA neurons in sham rats. In 6-OHDA lesioned rats, therapeutic SNpr stimulation inhibited significantly more VA neurons (43%), compared to sham rats, and only 19% of cells were excited. Data show that SNpr axon stimulation with an appropriate complex pattern inhibits VA neurons and is associated with improved movements. Our results highlight trialling complex patterns of electrical deep brain stimulation to treat the motor symptoms of PD.
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https://hal.inrae.fr/hal-02734887
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Submitted on : Tuesday, June 2, 2020 - 2:35:10 PM
Last modification on : Thursday, July 15, 2021 - 3:36:02 PM

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  • HAL Id : hal-02734887, version 1
  • PRODINRA : 477838

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Clémentine Bosch-Bouju, R.A. Smither, J.E. Prier, S.M. Hughes, Louise C. Parr-Brownlie. Stimulating SNpr – motor thalamus pathway in a Parkinsonian rat model modulates forelimb movement. 13. IBAGS Meeting, Apr 2019, Biaritz, France. 2019, Scientific Programme. ⟨hal-02734887⟩

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