The spread of Map between herds is mainly due to animal movements, which form a complex network linking farms geographically close or distant. Moreover, the diversity of farming systems in a region (dairy vs beef, variable herd size and structure) and of contacts among farms (frequency, types of animals purchased) can also influence Map spread and control at the scale of the metapopulation of herds. Here we study Map spread between cattle herds to evaluate, at a regional scale, control strategies based on the management of animal movements between herds depending on their epidemiological status. Regional infection dynamics are represented by coupling intra and inter herds dynamics. For each herd, a stochastic compartmental model in discrete time describes realistic population dynamics and Map spread accounting for all the transmission routes and detailed infection progression. Intra-­‐herds dynamics are coupled within a metapopulation model through animal movements. We use animal trade data from the French cattle identification database (2005–2009). A subset of the dairy farms network in the Finistère department in Northwestern France is considered based on the type and size of the herds. Various tests at purchase are implemented, defined by the test sensitivity (Se) and specificity, the animal age and status at purchase and the delay between the test and the removal of detected animals (no delay if testing occurred before animal introduction until a delay of a few weeks). The initial number of infected herds, their prevalence, and the network structure highly influence the speed of Map spread and the endemic state reached 20 to 50 years after the first disease occurrence. Testing purchased animals with Se greater than 0.75 achieves to stop Map spread but not to reduce the regional prevalence. Therefore, a combination of strategies should now be evaluated to also target a decrease in the within-­‐herd contamination level. In parallel, an extension to beef herds is under way.