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Maternal exposure to diesel exhaust during pregnancy affects postnatal health of the offspring, in a rabbit model

Abstract : Recent events related to pollution peaks have shown that we are continuously and insidiously submitted to air pollution. Epidemiological and experimental studies in rodents describe direct consequences on health with increasing respiratory and cardiovascular diseases and high susceptibility for metabolic diseases. Indirect consequences due to in utero exposure induce also intrauterine growth retardation in human. The goal of this study was to study the affects of in utero exposure to diesel exhausts, in rabbit , focusing on the characterization of F1 offspring's phenotype at adulthood. The phenotype of offspring animals has been studied from puberty to adulthood (7 .5 months) to evaluate the occurrence of cardio-metabolic disorders, by animal tracking (measurement of food intake, weight change) as well as cardio-metabolic functional tests (lasting blood analyses of lipid metabolism, analyses of body composition by iDXA, assessment of insulinaemic and glycemia response to a bolus of glucose during glucose tolerance test, blood pressure and heart rate measurements). Alter this in vivo experiment, the animals were euthanized and the insulin sensitive tissues were collected for biometry records. ln utero exposure to polluted air modified the adult offspring's phenotype, alter puberty, in a sex-specific manner. Polluted males exhibited a metabolic syndrome with hyperglycemia, more abdominal fat and rise of blood pressure with age compared to control males. Polluted males presented symptoms of hepatic steatosis (higher transaminase ALAT, heavier liver) and atherosclerosis (lower HDL-cholesterol). Polluted females presented hypertriglyceridemia and a decrease of bone mass and density compared to control tamale, indicating a higher susceptibility to bone pathologies. ln conclusion an indirect in utero exposure to air pollution was sufficient to affect durably the phenotype of animals that developed signs of insulin resistance with higher risk of cardiovascular morbidity, involving sax­specific pathways.
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Contributor : Migration Prodinra <>
Submitted on : Wednesday, June 3, 2020 - 12:17:27 AM
Last modification on : Tuesday, April 6, 2021 - 1:24:05 PM


  • HAL Id : hal-02740944, version 1
  • PRODINRA : 277247



Delphine Rousseau Ralliard, Pauline Hoarau, Christophe Richard, Marine Guinot, Marie-Sylvie Lallemand, et al.. Maternal exposure to diesel exhaust during pregnancy affects postnatal health of the offspring, in a rabbit model. 2. Colloque de la SF-DOHaD, Origine Développementale de la santé et des maladies et épigénétique, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Nov 2014, Nantes, France. 57 p. ⟨hal-02740944⟩



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