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Conference papers

Hormonal control of implantation

Abstract : In mammals, implantation represents a key step of pregnancy and its progression conditions not only the success of pregnancy but health of the offspring. Implantation requires a complex and specific uterine tissue, the endometrium, whose biological functions are tightly regulated by numerous signals, including steroids and polypeptide hormones. Endometrial tissue is endowed with dynamic properties that associate its ability to control the developmental trajectory of the embryo (driver property) and its ability to react to embryos displaying distinct capacities to develop to term (sensor property). Since dynamical properties of the endometrium can be affected by pre- and post-conceptional environment, determining how maternal hormonal signals and their biological actions are affected by environmental factors (e.g. nutrition, stress, infections) is mandatory to reduce or even to prevent their detrimental effects on endometrial physiology in order to preserve the optimal functionality of this tissue.
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Olivier Sandra. Hormonal control of implantation. 59. Journées Internationales d’Endocrinologie Clinique, Société Française d'Endocrinologie (SFE). FRA., Jun 2016, Paris, France. ⟨10.1016/j.ando.2016.04.013⟩. ⟨hal-02743260⟩



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