Fruits and vegetables (F&V) are an important source of valuable molecules, including flavonoids, polyphenols, terpenes, vitamins or dyes. After processing, current F&V industry generates considerable amounts of by-products that contain highly valued compounds, yet that are generally considered as waste. The valorization of food by-products has become a new challenge for industry and academics, which resulted in the development of the bio-refinery concept. Inspired by petrol chemistry refinery processes, it aims at recovering various materials from a single biomass. Here presented work is based on the original “dry” bio-refinery of food by-products. The novelty of this work relies on the extraction of compounds achieved without addition of solvent or water. The only water used in the process was the constitutive water extracted from the very biomass. To recover different fractions, bio-refinery concept was applied using green extraction processes (microwave and ultrasound assisted extraction) and quality of the corresponding extracts was determined. Ultimately, the performances of bio-refinery using green extraction and conventional extraction were compared as far as extraction performance, process time, energy consumption, quantity of waste and quantity of solvent, are concerned. The bio-refinery concept was applied to several F&V products. As far as ginger by-products (press cake recovered after juice processing) are concerned, the “dry” rather than the conventional bio-refinery appeared to be a greener process as it resulted in shorter time of extraction and in lower energy consumption and quantity of organic solvent used and in reduced amount of waste. Even though the extraction performance was lower as compared to the conventional bio-refinery, the objective of the study was achieved as the valorization of ginger by-products was total and it resulted in highly valued products without the use of additional solvents. Indeed, ginger rhizomes yielded in a juice, an essential oil, an extract rich in phenolics, and a solid residue rich in fibers and phenolic acids.