Molecular basis of virus resistance mediated by host factors required for the infectious cycle
Résumé
ln recent year, one of the most interesting results that has enabled plant virology to make a significant step forward is the identification of components of the translation initiation complex as essential host factors required for RNA virus multiplication. Although translation initiation factors were demonstrated to be highly conserved determinants of plant resistance to viruses, preliminary data indicate that the molecular basis underlying translation initiation factors-mediated resistance are highly variable. ln parallel, several recessive resistance genes against viruses were identified and demonstrated to be distinct from translation initiation factors. These genes are therefore very good candidates for the discovery of new susceptibility factors. ln this context, the MOVle project airns at (i) the characterization of mechanisms underlying molecular specificity of translation initiation factors mediated resistance, (ii) the study of the potential role of translation initiation factors in RNA virus resistance in economically important crops such as grapevine, and (iii) the identification of new host factors required for viral infection The project is likely to provide fundamental insights into the molecular basis of plant-virus interactions and to greatly facilitate the exploitation of host factors required for the viral cycle as targets to improve plant resistance to viruses.
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