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Impact of thermal properties on formulation and on freeze-drying development

Abstract : Freeze-drying continues to increase in importance due to the widespread development of protein therapeutic agents. This results in a great interest in analytical approaches to formulation and process development based on a better understanding of the physical chemistry of freezing and freeze-drying. This article describes how two analytical methods, differential scanning calorimetry and freeze-drying microscopy can help the formulation scientist to develop the optimum freeze-dried protein formulation allowing the most efficient freeze-drying process.
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Submitted on : Wednesday, June 3, 2020 - 5:58:41 PM
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  • HAL Id : hal-02751565, version 1
  • PRODINRA : 333886



Stéphanie Passot, Fernanda Fonseca, Michèle Marin. Impact of thermal properties on formulation and on freeze-drying development. Conférence de l'Institut International du Froid (IIF), Institut International du Froid (IIF). FRA., Nov 2007, Strasbourg, France. ⟨hal-02751565⟩



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