Antagonists for use in commercial biocontrol products have to fulfill many different requirements. Besides being active control agents against the specific targeted plant pathogens, they must be safe and cost effective. The development of new biocontrol products starts with screening programs including hundreds or thousands of candidates. For commercial use, important criteria are market size, efficacy, ecological characteristics, production costs, safety, environmental risks and protection of intellectual property rights. A stepwise screening considering these very different aspects is proposed.