Exploration of somatotropic axis, leptin, insulin and blood biochemical parameters in ewes naturally affected with scrapie
Résumé
Scrapie is an ovine sub-acute transmissible spongiform encephalopathy (TSE) caused by unconventional transmissible agents. In several species, TSE are associated to major endocrinopathy, such as hyperinsulinemia and hypercorticism (Carp et al, 1990, Gayrard et al, 2000). Cachexia is commonly observed in the clinical phase of the prion disease. Our objective was to investigate if scrapie is associated to alterations of GH axis, leptin, insulin and metabolic parameters. In addition, central adrenergic system being affected in TSE (Braun et al, 1999), we investigated a possible alteration of a2-adrenergic control of GH axis associated to the prion disease.
Domaines
Sciences du Vivant [q-bio]
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