Communication in social insects is one of the more fascinating areas for understanding their biology and sociality. Chemical communication has been extensively studied in the honeybee and its key in social regulations between individuals. Honeybees of different castes, sexes and ages interact using pheromones, more or less volatile chemical components produced by the bees having different effects in the receivers of the colony. When hormones are acting inside the individuals, pheromones are produced outside. They can produce releaser pheromones, triggering specific behaviours. For example, the alarm pheromones are produced by the guard bees at the entrance of the hive and initiate the stinging behaviour of the soldiers of the colony, which then exit the nest and sting the intruder.Other examples are the queen mandibular pheromone, acting as a sex pheromone, or the Nasavov pheromone, orienting homecoming of worker bees back to the colony. Many releaser pheromones have been identified in insects and the animal kingdom. Such is not the case of the primer pheromones, inducing deep changes on the physiology of the receivers. Only a few of them have been discovered, mostly in the honeybee, which make a wonderful model to study social insects.