The risk of resistance evolution in insects to transgenic insecticidal crops, Collection of Biosafety Reviews, vol.4, pp.142-199, 2008. ,
Avis relatif à une demande d'autorisation de mise sur le marché, au titre du Règlement (CE) n° 1829/2003 relatif aux denrées et aux aliments pour animaux génétiquement modifiés, du maïs génétiquement modifié 4114, développé pour être résistant à certains insectes et tolérant au glufosinate-ammonium, pour l'importation, la transformation ainsi que l'utilisation en alimentation humaine et animale de cet OGM, 2015. ,
Téosinte, une adventice qui demande une vigilance toute particulière, p.4, 2013. ,
Pollen-mediated gene flow in maize: Implications for isolation requirements and coexistence in Mexico, the center of origin of maize, PLoS One, vol.10, 2015. ,
Pollination between maize and teosinte: an important determinant of gene flow in Mexico, Theor Appl Genet, vol.110, pp.519-526, 2005. ,
Cross-pollination of maize at long distance, Eur J Agron, vol.27, pp.44-51, 2007. ,
Histopathological effects of Bt and TcdA insecticidal proteins on the midgut epithelium of Western corn rootworm larvae (Diabrotica virgifera virgifera), Toxins, vol.9, p.14, 2017. ,
Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control, Toxicon, vol.49, pp.423-435, 2007. ,
, , 1991.
Fate of maize intrinsic and recombinant genes in calves fed genetically modified maize Bt11, J Food Prot, vol.67, pp.365-370, 2004. ,
Redox regulation of plant development, Antioxidants & Redox Signaling, vol.21, pp.1305-1326, 2017. ,
on guidelines for the development of national co-existence measures to avoid the unintended presence of GMOs in conventional and organic crops, Official Journal of the European Union, vol.01, pp.1-5, 0200. ,
Commission recommendation 2014/63/EU of 6 February 2014 on measures to control Diabrotica virgifera virgifera Le Conte in Union areas where its presence is confirmed, Official Journal of the Europea Union, vol.38, pp.46-48, 2014. ,
Scientific opinion on statistical considerations for the safety evaluation of GMOs, on request of EFSA, question n° EFSA-Q-2006-080, The EFSA Journal, vol.8, issue.1, p.59, 2010. ,
Scientific Opinion on the assessment of potential impacts of genetically modified plants on non-target organisms, The EFSA Journal, vol.8, issue.11, p.1877, 2010. ,
Guidance on the agronomic and phenotypic characterisation of genetically modified plants, EFSA Journal, vol.13, issue.6, p.44, 2015. ,
Relevance of new scientific evidence on the occurrence of teosinte in maize fields in Spain and France for previous environmental risk assessment conclusions and risk management recommendations on the cultivation of maize events MON810, Bt11, 1507 and GA21, 2016. ,
, Technical report on the explanatory note on DNA sequence similarity searches in the context of the assessment of horizontal gene transfer from plants to microorganisms, EFSA Supporting publication, vol.2017, 2017.
EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms) Scientific Opinion. Assessment of genetically modified maize 4114 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2014-123), EFSA Journal, vol.16, issue.5, p.25, 2018. ,
Novel Bacillus thuringiensis binary insecticidal crystal proteins active on western corn rootworm, Diabrotica virgifera virgifera LeConte, Appl Environ Microbiol, vol.68, pp.1137-1145, 2002. ,
Spontaneous hybridization between maize and teosinte, J Hered, vol.98, pp.183-187, 2007. ,
Terms and Conditions for Bt Corn Registrations. Office of Pesticide Programs, 2010. ,
, implementing Regulation (EC) No 1107/2009 of the European Parliament and of the Council as regards the list of approved active substances, Commission implementing Regulation, vol.540, pp.1-186, 2011.
, laying down the methods of sampling and analysis for the official control of feed as regards presence of genetically modified material for which an authorisation procedure is pending or the authorisation of which has expired, Commission Regulation, vol.619, pp.9-15, 2011.
, amending Implementing Regulation (EU) No 540/2011 as regards the conditions of approval of the active substance glufosinate, Commission implementing Regulation, vol.365, pp.27-29, 2013.
, on applications for authorisation of genetically modified food and feed in accordance with Regulation (EC) No 1829/2003 of the European Parliament and of the Council and amending Commission Regulations (EC) No 641, Commission Implementing Regulation, vol.157, pp.1-48, 1981.
, , 2010.
Bt crops and insect pests: past successes, future challenges and opportunities, GM crops & food, vol.3, pp.139-139, 2012. ,
Transformation of Acinetobacter sp. strain BD413 by transgenic sugar beet DNA, Appl Environ Microbiol, vol.64, pp.1550-1554, 1998. ,
Toxicity and mode of action of Bacillus thuringiensis Cry proteins in the Mediterranean corn borer, Sesamia nonagrioides (Lefebvre), Appl Environ Microbiol, vol.72, pp.2594-2600, 2006. ,
Toxicity and mode of action of Bacillus thuringiensis Cry proteins in the Mediterranean corn borer, Sesamia nonagrioides (Lefebvre), Appl Environ Microbiol, vol.72, pp.2594-2600, 2006. ,
Bacillus thuringiensis crystal proteins CRY1Ab and CRY1Fa share a high affinity binding site in Plutella xylostella (L.), Biochem Biophys Res Commun, vol.224, pp.779-783, 1996. ,
Adaptation and Invasiveness of Western Corn Rootworm: Intensifying Research on a Worsening Pest, In Annu Rev Entomol, pp.303-321, 2009. ,
Fate of recombinant DNA and Cry1Ab protein after ingestion and dispersal of genetically modified maize in comparison to rapeseed by fallow deer (Dama dama), European Journal of Wildlife Research, vol.54, pp.36-43, 2008. ,
Isolation of maize from pollen-mediated gene flow by time and distance, Crop Sci, vol.45, pp.2172-2185, 2005. ,
Monitoring the occurrence of genetically modified maize in Korea: A 3-year observations, Journal of the Faculty of Agriculture Kyushu University, vol.60, pp.285-290, 2015. ,
, , 2013.
, Spontaneous renal tumors in two rats from a thirteen week rodent feeding study with grain from molecular stacked trait lepidopteran and coleopteran resistant (DP-ØØ4114-3) maize, Food Chem Toxicol, vol.53, pp.428-431
17 du Haut Conseil des biotechnologies sur la coexistence : définition des conditions techniques relatives à la mise en culture, la récolte, le stockage et le transport des végétaux génétiquement modifiés visant à éviter la présence accidentelle d'OGM dans d'autres productions, p.46, 2012. ,
17 du Comité scientifique du HCB relatif à une demande d'autorisation de mise sur le marché du maïs génétiquement modifié 1507x59122 à des fins de culture, d'importation, de transformation et d'alimentation humaine et animale (dossier EFSA-GMO-NL, Disponible sur, p.73, 2005. ,
Monarch larvae sensitivity to Bacillus thuringiensis-purified proteins and pollen, Proc Natl Acad Sci U S A, vol.98, pp.11925-11930, 2001. ,
Binary insecticidal crystal protein from Bacillus thuringiensis, strain PS149B1: Effects of individual protein components and mixtures in laboratory bioassays, J Econ Entomol, vol.95, pp.635-639, 2002. ,
Metagenomic-based impact study of transgenic grapevine rootstock on its associated virome and soil bacteriome, Plant Biotechnol J, vol.16, pp.208-220, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01588179
Evaluation of the nutritive value of maize for honey bees, J Insect Physiol, vol.58, pp.278-285, 2012. ,
Maize pollen deposition in relation to distance from the nearest pollen source under common cultivation -results of 10 years of monitoring, Environmental Sciences Europe, vol.26, pp.1-14, 2001. ,
Silencing of OsGRXS17 in rice improves drought stress tolerance by modulating ROS accumulation and stomatal closure, 2017. ,
Binding analyses of Bacillus thuringiensis Cry delta-endotoxins using brush border membrane vesicles of Ostrinia nubilalis, Appl Environ Microbiol, vol.67, pp.872-879, 2001. ,
Binding analyses of Bacillus thuringiensis Cry delta-endotoxins using brush border membrane vesicles of Ostrinia nubilalis, Appl Environ Microbiol, vol.67, pp.872-879, 2001. ,
Teosinte as a model system for population and ecological genomics, Trends Genet, vol.28, pp.606-615, 2012. ,
The genomic signature of crop-wild introgression in maize, PLoS Genet, vol.9, 2013. ,
Determining whether transgenic and endogenous plant DNA and transgenic protein are detectable in muscle from swine fed Roundup Ready soybean meal, J Anim Sci, vol.81, pp.1447-1455, 2003. ,
Acute and repeated dose (28 day) mouse oral toxicology studies with Cry34Ab1 and Cry35Ab1 Bt proteins used in coleopteran resistant DAS-59122-7 corn, Regul Toxicol Pharmacol, vol.54, pp.154-163, 2009. ,
Environmental effects on long-range outcrossing rates in maize, Agric Ecosyst Environ, vol.142, pp.410-418, 2011. ,
In situ transfer of antibiotic resistance genes from transgenic (transplastomic) tobacco plants to bacteria, Appl Environ Microbiol, vol.68, pp.3345-3351, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-02399924
Structural and biophysical characterization of Bacillus thuringiensis insecticidal proteins Cry34Ab1 and Cry35Ab1, PLoS One, vol.9, p.15, 2014. ,
Pollen nutrition and colony development in honey bees: part I, Bee World, vol.86, pp.3-10, 2005. ,
Can transgenic crops go wild? A literature study on using plant traits for weediness pre-screening, COGEM Research Report, pp.2012-2013, 2011. ,
Chilling stress in maize: from physiology to genetics and molecular mechanisms. A Habilitation Thesis in Crop Science, Department of Agricultural and Food Sciences, p.122, 2009. ,
Bacillus thuringiensis Cry34Ab1/Cry35Ab1 Interactions with Western Corn Rootworm Midgut Membrane Binding Sites, PLoS One, vol.8, 2013. ,
Maize pollen longevity and distance isolation requirements for effective pollen control, Crop Sci, vol.41, pp.1551-1557, 2001. ,
Extent of cross-fertilization in maize by pollen from neighboring transgenic hybrids, Crop Sci, vol.44, pp.1273-1282, 2004. ,
Etude de la dynamique des populations des chenilles de Spodoptera frugiperda Abbot & Smith et d'Heliothis zea Boddie (Lepidoptera noctuidae) sur deux variétés de maïs en Guadeloupe (Antilles françaises), Agronomie, vol.1, pp.701-706, 1981. ,
Gene flow from glyphosate-resistant crops, Pest Manage Sci, vol.64, pp.428-440, 2008. ,
Diurnal foraging activity for corn pollen by honey bees (Hymenoptera, Apidae), Environ Entomol, vol.11, pp.187-188, 1982. ,
A novel Bacillus thuringiensis (PS149B1) containing a Cry34Ab1/Cry35Ab1 binary toxin specific for the western corn rootworm Diabrotica virgifera virgifera LeConte forms ion channels in lipid membranes, Biochemistry (Mosc), vol.43, pp.12349-12357, 2004. ,
A single domestication for maize shown by multilocus microsatellite genotyping, Proc Natl Acad Sci, vol.99, pp.6080-6084, 2002. ,
Thioredoxins and glutaredoxins: unifying elements in redox biology, Annu Rev Genet, vol.43, pp.335-367, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00685724
, , 2008.
, Glutaredoxins and thioredoxins in plants, Biochim Biophys Acta-Mol Cell Res, vol.1783, pp.589-600
Multiple transatlantic introductions of the western corn rootworm, Science, vol.310, p.992, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02682039
Insecticidal proteins from Bacillus thuringiensis protect corn from corn rootworms, Nat Biotechnol, vol.19, pp.668-672, 2001. ,
Safety considerations derived from Cry34Ab1/Cry35Ab1 structure and function, J Invertebr Pathol, vol.142, pp.27-33, 2017. ,
Sensitive PCR analysis of animal tissue samples for fragments of endogenous and transgenic plant DNA, J Agric Food Chem, vol.52, pp.6129-6135, 2004. ,
Assessing the survival of transgenic plant DNA in the human gastrointestinal tract, Nat Biotechnol, vol.22, pp.204-209, 2004. ,
Respective role of the 42-and 51-kDa components of the Bacillus sphaericus toxin overexpressed in Bacillus thuringiensis, FEMS Microbiol Lett, vol.106, pp.275-280, 1993. ,
Assessment of the influence of field size on maize gene flow using SSR analysis, Transgenic Res, vol.21, pp.471-483, 2012. ,
Bacillus thuringiensis toxins: an overview of their biocidal activity, Toxins, vol.6, pp.3296-3325, 2014. ,
El Teosinte (Zea mays, spp, Informaciones Técnicas GIoberno del Aragone, p.6, 2014. ,
Presencia de teosinte (Zea spp.) como mala hierba en los regadíos del valle del Ebro, XV Congreso de la Sociedad Española de Malherbología: La Malherbología y la transferencia tecnológica, pp.417-423, 2015. ,
Monitoring the occurrence of genetically modified maize at a grain receiving port and along transportation routes in the Republic of Korea, Food Control, vol.21, pp.456-461, 2010. ,
Effects of a mosquitocidal toxin on a mammalian epithelial cell line expressing its target receptor, Cell Microbiol, vol.7, pp.1335-1344, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00091135
, , 2005.
, Bacillus thuringiensis subsp israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor, Proc Natl Acad Sci, vol.102, pp.18303-18308
Assessment of real-time PCR based methods for quantification of pollen-mediated gene flow from GM to conventional maize in a field study, Transgenic Res, vol.15, pp.219-228, 2006. ,
, , 2009.
Assessing the ecological risks from the persistence and spread of feral populations of insect-resistant transgenic maize, Transgenic Res, vol.21, pp.655-664, 2012. ,
Dispersion and deposition of corn pollen from experimental sources, Agron J, vol.64, p.420, 1972. ,
Strategy for in situ detection of natural transformation-based horizontal gene transfer events, Appl Environ Microbiol, vol.74, pp.1250-1254, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00312918
Historical divergence and gene flow in the genus Zea, Genetics, vol.181, pp.1399-1413, 2009. ,
Plant glutaredoxins: pivotal players in redox biology and iron-sulphur centre assembly, New Phytol, vol.186, pp.365-372, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-02663806
Genome-wide analysis of plant glutaredoxin systems, J Exp Bot, vol.57, pp.1685-1696, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02545530
Bacillus thuringiensis and its pesticidal crystal proteins, Microbiol Mol Biol Rev, vol.62, pp.775-806, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-02696151
Characterization of Cry34/Cry35 binary insecticidal proteins from diverse Bacillus thuringiensis strain collections, Appl Environ Microbiol, vol.71, pp.1765-1774, 2005. ,
Permeabilization of model lipid membranes by Bacillus sphaericus mosquitocidal binary toxin and its individual components, J Membr Biol, vol.184, pp.171-183, 2001. ,
Detection of transgenic and endogenous plant DNA in digesta and tissues of sheep and pigs fed Roundup Ready canola meal, J Agric Food Chem, vol.54, pp.1699-1709, 2006. ,
Synthesis and overview studies to evaluate existing research and knowledge on biological issues on GM plants of relevance to Swiss environments. (vdf Hochschulverlag AG an der ETH Zürich, 2012. ,
Pollen-mediated gene flow in maize tested for coexistence of GM and non-GM crops in the Netherlands: effect of isolation distances between fields, Njas-Wageningen Journal of Life Sciences, vol.7, pp.405-423, 2009. ,
Impact of topography on cross-pollination in maize (Zea mays L.), Eur J Agron, vol.31, pp.99-102, 2009. ,
Gene flow among different teosinte taxa and into the domesticated maize gene pool, Genet Resour Crop Evol, vol.58, pp.1243-1261, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02650119
Fate of genetically modified maize and conventional rapeseed, and endozoochory in wild boar (Sus scrofa), Mammalian Biology, vol.74, pp.193-199, 2009. ,
Nutritional assessment and fate of DNA of soybean meal from roundup ready or conventional soybeans using rats, Arch Anim Nutr, vol.58, pp.295-310, 2004. ,
, Annexe 2 : Elaboration de l'avis
, Cet avis a été élaboré par le CS du HCB à partir de la discussion de rapports d'expertise et d'un projet d'avis en séance du 14 juin 2018 36 sous la présidence du Dr Jean-Christophe Pagès et la vice
HCB est un comité pluridisciplinaire composé de personnalités scientifiques nommées par décret au titre de leur spécialité en relation avec les missions du HCB ,
, Eliane Meurs, Nadia Naffakh, Didier Nègre
, Le dossier a été examiné par huit experts rapporteurs du CS du HCB sélectionnés pour leurs compétences dans les disciplines requises pour l'analyse du dossier
, Ayant participé à l'élaboration de l'avis de l'EFSA en tant que membre du panel OGM de l'EFSA, Philippe Guerche n'a contribué ni à l'analyse de ce dossier, ni à l'élaboration de cet avis, Les membres du CS du HCB remplissent annuellement une déclaration publique d'intérêts
, Membres du CS présents et représentés lors de la discussion du projet d'avis en séance du, vol.14, 2018.
, Composition du CS en vigueur suite au décret de nomination des membres du HCB du 30 décembre, 2014.