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Conference Papers Year : 2019

Using a hybrid approach to model central carbon metabolism across the cell cycle

Abstract

Metabolism and cell cycle are two central processes in the life of a eukaryote cell. If they have been extensively studied in their own right, their interconnection remains relatively poorly understood. In this paper, we propose to use a differential model of the central carbon metabolism. After verifying the model accurately reproduces known metabolic variations during the cell cycle’s phases, we extend it into a hybrid system reproducing an imposed succession of the phases. This first hybrid approach qualitatively recovers observations made in the literature, providing an interesting first step towards a better understanding of the crosstalks between cell cycle and metabolism.
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Dates and versions

hal-02791386 , version 1 (05-06-2020)

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Cecile Moulin, Laurent Tournier, Sabine Pérès. Using a hybrid approach to model central carbon metabolism across the cell cycle. International Workshop on Hybrid Systems Biology, Apr 2019, Prague, Czech Republic. ⟨10.1007/978-3-030-28042-0_9⟩. ⟨hal-02791386⟩
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