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Using a hybrid approach to model central carbon metabolism across the cell cycle

Abstract : Metabolism and cell cycle are two central processes in the life of a eukaryote cell. If they have been extensively studied in their own right, their interconnection remains relatively poorly understood. In this paper, we propose to use a differential model of the central carbon metabolism. After verifying the model accurately reproduces known metabolic variations during the cell cycle’s phases, we extend it into a hybrid system reproducing an imposed succession of the phases. This first hybrid approach qualitatively recovers observations made in the literature, providing an interesting first step towards a better understanding of the crosstalks between cell cycle and metabolism.
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https://hal.inrae.fr/hal-02791386
Contributor : Migration Prodinra <>
Submitted on : Friday, June 5, 2020 - 7:39:07 AM
Last modification on : Thursday, July 8, 2021 - 3:49:51 AM

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Cecile Moulin, Laurent Tournier, Sabine Pérès. Using a hybrid approach to model central carbon metabolism across the cell cycle. Hybrid Systems Biology, 11705 (Chapter 9), Češka M., Paoletti N. (eds), 2019, Lecture Notes in Computer Science, ⟨10.1007/978-3-030-28042-0_9⟩. ⟨hal-02791386⟩

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