In term of contribution to pregnancy, the mother not only produces oocytes but she also hosts the whole gestation, mainly in the uterus. Persistent or transient modifications in organisation and functionality of uterine endometrium have been demonstrated to dramatically affect pre-implantation embryo trajectory through epigenetic alterations with lasting consequences on subsequent progression of pregnancy and post-natal development. Distinct endometrial responses can also be elicited by embryos presenting distinct post-implantation fates, e. g. when generated by in vitro fertilization or by somatic cell nuclear transfer. Based on a selection of recent findings, I will illustrate the driver and sensor properties of endometrium in mammals. Hence, optimising quality of this tissue can be proposed as a mean to increase term pregnancy rate provided that treatments aiming to improve endometrial environment are devoid of detrimental effects on offspring health.