In the context of the development of Serious Games, this position paper sheds light on their possible use to support and enhance social inclusion through the presentation of three research projects in this domain. We first describe the context of our works and research. We then report on several events joining the scientific community that focused on the research on Digital Games for Empowerment and Inclusion. Last, we propose some results of our experience in this domain. The presented work particularly highlights the importance of user-centered design in interdisciplinary cooperation with psychologists, sociologists, vulnerable end users and the practitioners. We stress the relevance of progress beyond the state-of-the-art in recently focused areas of AI, such as, in computational theory-of-mind, in affective multimodal computing, in learning of socio-emotional skills, and in recovery of human attention processes. Typical examples are given to illustrate the projects' research results.