MetaboHUB and RFMF are two tools developed in France to serve the scientific community in Metabolomics and Fluxomics (M&F). The French Metabolomics and Fluxomics Network (RFMF, https://www.bordeaux.inra.fr/ifr103/reseau_metabolome/) is a scientific society which contributes to the development of M&F and more broadly to the overall analysis of metabolism in France through various actions: • Foster relationships between French researchers working in the world of M&F (public and private sectors); • Promote and structure education and training in M&F; • Organize and support the organization of conferences in France and abroad; • Encourage the participation of young researchers to national and international conferences through grants; • Allocate funds mission or prizes for accomplished work in M&F. MetaboHUB project (http://www.metabohub.fr/en/) aims at creating a national infrastructure that will place France among the European leaders for advanced research services in M&F. MetaboHUB provides equipment and services to academic research and industrial partners in nutrition, health, agriculture, environment and biotechnology. MetaboHUB is the merging of 4 existing facilities (Bordeaux, Paris-Saclay, Toulouse and Clermont-Ferrand) into a unique infrastructure sharing common regulations and complementary M&F tools. Besides providing state-of-the-art services and support to national and international projects, a major ambition of MetaboHUB is to develop innovative tools and methods to address critical biological questions. MetaboHUB will provide custom solutions for (i) high-throughput, quantitative technologies for biochemical phenotyping of large sets of samples and for systems biology through standardization and combination of state–of-art technologies, (ii) identification of metabolites in human biofluids, plants, microorganisms and animal cell extracts, through the implementation and maintenance of centralized and open spectral repositories for metabolome annotations, (iii) large-scale flux profiling and sub-cellular fluxomics through integration of analytical data from multiple analytical devices, (iv) access to high-impact services to the national scientific community and industrial actors and, (v) attracting and training a new generation of scientists and students.