Aerobic exercise performance and 4-weeks AICAR treatment in myostatin-deficient aged mice - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Conference Papers Year : 2011

Aerobic exercise performance and 4-weeks AICAR treatment in myostatin-deficient aged mice

Abstract

This study examined the aerobic running performance of myostatin-deficient aged mice (Mstn-/-), a hypermuscular genetic model. Next, the effects of activating AMP-activated protein kinase on aerobic exercise performance was analysed by 4-weeks treatment of 5-aminoimidazole-4-carboxamide (AICAR), a known inducer of mitochondrial biogenesis. The results showed reduced aerobic running performance in mstn-deficient aged mice, especially in endurance. AICAR treatment induced no significant improvement in aerobic exercise parameters in mice, but reduced differences in endurance capacity between Mstn-/-and Mstn +/+. Biological analysis are currently in process to identify the mitochondria mechanisms involved.

Domains

Animal biology
No file

Dates and versions

hal-02803745 , version 1 (05-06-2020)

Identifiers

  • HAL Id : hal-02803745 , version 1
  • PRODINRA : 443517

Cite

Marion Pauly, Béatrice Chabi, Stefan Matecki, François Bertrand Favier, Barbara B. Vernus, et al.. Aerobic exercise performance and 4-weeks AICAR treatment in myostatin-deficient aged mice. 14. Congrès International de l'ACAPS (Association des Chercheurs en Activités Physiques et Sportives), Oct 2013, Rennes, France. 2 p. ⟨hal-02803745⟩
20 View
0 Download

Share

Gmail Facebook X LinkedIn More