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Communication Dans Un Congrès Année : 2011

Heterogeneity of persistence and infectivity of Salmonella Senftenberg strains

Résumé

In poultry production, Salmonella Senftenberg has always been associated to the hatchery environment, but has recently become more frequent in poultry farms. Furthermore, some strains were responsible of several human infections throughout the world. In order to explain the emergence of persistent clones in poultry houses, we identified strains showing different persistence phenotypes in chickens. The non-persistent strains were eliminated progressively after the first week of infection, while the persistent strains were able to colonize the caeca of chickens at high levels similar to S. Enteritidis. The assessment of the pathogenicity of these two phenotypes showed that all S. Senftenberg strains, contrary to S. Enteritidis were able to induce a strong systemic infection neither in orally infected mice and chickens nor in mice infected subcutaneously. The in vitro analysis with epithelial cells and macrophages suggests that this poor infectivity could be related to an alteration in their capacity to invade nonphagocytic cells. The comparison between persistent and non-persistent S. Senftenberg strains showed that persistent strains are more able to colonize and persist in spleen of chickens and mesenteric lymph-nodes of mice. No difference has been observed between these strains in their ability to grow in the caecal content. All together, our findings suggest that the existence of distinct persistent phenotypes within S. Senftenberg could explain the recent emergence of this serotype in poultry flocks and the higher capacity of persistent strains to colonize the animal tissues could be a possible explanation for this increased persistence.
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Dates et versions

hal-02804898 , version 1 (05-06-2020)

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  • HAL Id : hal-02804898 , version 1
  • PRODINRA : 49154

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Zineb Boumart, Sylvie Roche, Isabelle Virlogeux-Payant, Marianne Chemaly, Philippe Velge. Heterogeneity of persistence and infectivity of Salmonella Senftenberg strains. 2011 PhD Day, Oct 2011, Nouzilly, France. 1p. ⟨hal-02804898⟩
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