While biocontrol is commonly used for the protection of greenhouse crops against arthropods, continued reliance on chemical control against diseases is often considered as a hindrance to integrated protection. This paper presents a review of currently available biocontrol products and other alternatives to pesticides for use against plant diseases in the Mediterranean greenhouse. At least 12 biological active substances (micro-organism or plant extract) are commercially available for the control of soilborne pathogens and 14 against foliar diseases, in one country or more in the Mediterranean Basin. Future prospects and challenges are presented.