M. S. Alaejos and A. M. Afonso, Factors That Affect the Content of Heterocyclic Aromatic Amines in Foods, Comprehensive Reviews in Food Science and Food Safety, vol.10, issue.2, pp.52-108, 2011.

C. Alland, F. Moreews, D. Boens, M. Carpentier, S. Chiusa et al., RPBS: a web resource for structural bioinformatics, Nucleic Acids Research, vol.33, issue.Web Server, pp.W44-W49, 2005.
URL : https://hal.archives-ouvertes.fr/inria-00180478

Y. Wong, H. Cantalloube, J. Chomilier, J. Hochez, J. Pothier et al., , p.648

J. F. Zagury and P. Tufféry, RPBS: a web resource for structural 649 bioinformatics, Nucleic Acids Research, vol.33, pp.44-49, 2005.

A. D. Andricopulo, L. B. Salum, and D. J. Abraham, Structure-Based Drug Design Strategies in Medicinal Chemistry, Current Topics in Medicinal Chemistry, vol.9, issue.9, pp.771-790, 2009.

R. S. Bohacek, C. Mcmartin, and W. C. Guida, The art and practice of structure-based drug design: A molecular modeling perspective, Medicinal Research Reviews, vol.16, issue.1, pp.3-50, 1996.

R. Busquets, L. Puignou, M. T. Galceran, and K. Skog, Effect of Red Wine Marinades on the Formation of Heterocyclic Amines in Fried Chicken Breast, Journal of Agricultural and Food Chemistry, vol.54, issue.21, pp.8376-8384, 2006.

K. W. Cheng, F. Chen, and M. Wang, Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties, Molecular Nutrition & Food Research, vol.51, issue.8, pp.969-976, 2007.

K. W. Cheng, C. C. Wong, J. Chao, C. Lo, F. Chen et al., Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde, Molecular Nutrition & Food Research, vol.53, issue.6, pp.716-725, 2009.

S. Chevolleau, C. Touzet, E. Jamin, J. Tulliez, and L. Debrauwer, Dosage par LC-APCI-MS/MS des amines aromatiques hétérocycliques formées lors de la cuisson des viandes, Sciences des Aliments, vol.27, issue.6, pp.381-395, 2007.

J. Dama?ius, P. R. Venskutonis, R. Ferracane, and V. Fogliano, Assessment of the influence of some spice extracts on the formation of heterocyclic amines in meat, Food Chemistry, vol.126, issue.1, pp.149-156, 2011.

J. S. Dambolena, M. P. Zunino, E. I. Lucini, R. Olmedo, E. Banchio et al., Total Phenolic Content, Radical Scavenging Properties, and Essential Oil Composition ofOriganumSpecies from Different Populations, Journal of Agricultural and Food Chemistry, vol.58, issue.2, pp.1115-1120, 2010.

H. Dong, Y. Xian, H. Li, W. Bai, and X. Zeng, Potential carcinogenic heterocyclic aromatic amines (HAAs) in foodstuffs: Formation, extraction, analytical methods, and mitigation strategies, Comprehensive Reviews in Food Science and Food Safety, vol.19, issue.2, pp.365-404, 2020.

M. Friedman, L. Zhu, Y. Feinstein, and S. Ravishankar, Carvacrol Facilitates Heat-Induced Inactivation of Escherichia coli O157:H7 and Inhibits Formation of Heterocyclic Amines in Grilled Ground Beef Patties, Journal of Agricultural and Food Chemistry, vol.57, issue.5, pp.1848-1853, 2009.

M. Gibis and J. Weiss, Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties, Food Chemistry, vol.134, issue.2, pp.766-774, 2012.

P. A. Guy, E. Gremaud, J. Richoz, and R. J. Turesky, Quantitative analysis of mutagenic heterocyclic aromatic amines in cooked meat using liquid chromatography?atmospheric pressure chemical ionisation tandem mass spectrometry, Journal of Chromatography A, vol.883, issue.1-2, pp.89-102, 2000.

S. M. Henning, C. Fajardo-lira, H. W. Lee, A. A. Youssefian, V. L. Go et al., Catechin Content of 18 Teas and a Green Tea Extract Supplement Correlates With the Antioxidant Capacity, Nutrition and Cancer, vol.45, issue.2, pp.226-235, 2003.

C. Inocencio, D. Rivera, F. Alcaraz, and F. A. Tomás-barberán, Flavonoid content of commercial capers ( Capparis spinosa, C. sicula and C. orientalis ) produced in mediterranean countries, European Food Research and Technology, vol.212, issue.1, pp.70-74, 2000.

M. R. Khan, M. Naushad, Z. A. Alothman, M. S. Algamdi, I. H. Alsohaimi et al., Effect of Natural Food Condiments on Carcinogenic/Mutagenic Heterocyclic Amines Formation in Thermally Processed Camel Meat, Journal of Food Processing and Preservation, vol.41, issue.1, p.e12819, 2016.

A. , Effect of Natural Food Condiments on Carcinogenic/Mutagenic, 2017.

M. R. Khan, M. Naushad, Z. A. Alothman, M. S. Algamdi, I. H. Alsohaimi et al., Effect of Natural Food Condiments on Carcinogenic/Mutagenic Heterocyclic Amines Formation in Thermally Processed Camel Meat, Journal of Food Processing and Preservation, vol.41, issue.1, p.e12819, 2016.

D. R. Koes and C. J. Camacho, ZINCPharmer: pharmacophore search of the ZINC database, Nucleic Acids Research, vol.40, issue.W1, pp.W409-W414, 2012.

A. Kondjoyan, S. Chevolleau, E. Grève, P. Gatellier, V. Santé-lhoutellier et al., Formation of heterocyclic amines in slices of Longissimus thoracis beef muscle subjected to jets of superheated steam, Food Chemistry, vol.119, issue.1, pp.19-26, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00939535

C. Touzet, S. Portanguen, and L. Debrauwer, Formation of heterocyclic amines 706 in slices of Longissimus thoracis beef muscle subjected to jets of superheated steam. 707 Food Chemistry, vol.119, pp.19-26, 2010.

S. Y. Lee, Y. B. Jang, K. P. Kang, W. Y. Kim, S. Y. Lee et al., A dilemma in treating angiomyolipoma in a horseshoe kidney, Clinical Nephrology, vol.66, issue.09, pp.220-222, 2006.

K. Sang-jin and S. J. Hur, Overview of the effect of natural products on reduction 711 of potential carcinogenic substances in meat products, Trends in Food Science & 712 Technology, vol.99, pp.568-579, 2020.

C. A. Lipinski, Lead- and drug-like compounds: the rule-of-five revolution, Drug Discovery Today: Technologies, vol.1, issue.4, pp.337-341, 2004.

A. Melo, O. Viegas, C. Petisca, O. Pinho, and I. M. Ferreira, Effect of Beer/Red Wine Marinades on the Formation of Heterocyclic Aromatic Amines in Pan-Fried Beef, Journal of Agricultural and Food Chemistry, vol.56, issue.22, pp.10625-10632, 2008.

M. Meurillon and E. Engel, Mitigation strategies to reduce the impact of heterocyclic aromatic amines in proteinaceous foods, Trends in Food Science & Technology, vol.50, pp.70-84, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02639644

W. Ni, L. Mcnaughton, D. M. Lemaster, R. Sinha, and R. J. Turesky, Quantitation of 13 Heterocyclic Aromatic Amines in Cooked Beef, Pork, and Chicken by Liquid Chromatography?Electrospray Ionization/Tandem Mass Spectrometry, Journal of Agricultural and Food Chemistry, vol.56, issue.1, pp.68-78, 2008.

. Chem, Reviews, Language & History, vol.56, issue.1, pp.68-78, 2013.

A. Oguri, M. Suda, Y. Totsuka, T. Sugimura, and K. Wakabayashi, Inhibitory effects of antioxidants on formation of heterocyclic amines, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.402, issue.1-2, pp.237-245, 1998.

C. Planche, J. Ratel, P. Blinet, F. Mercier, M. Angénieux et al., Effects of pan cooking on micropollutants in meat, Food Chemistry, vol.232, pp.395-404, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02628335

I. Quelhas, C. Petisca, O. Viegas, A. Melo, O. Pinho et al., Effect of green tea marinades on the formation of heterocyclic aromatic amines and sensory quality of pan-fried beef, Food Chemistry, vol.122, issue.1, pp.98-104, 2010.

I. Quelhas, C. Petisca, O. Viegas, A. Melo, O. Pinho et al., Effect of green tea marinades on the formation of heterocyclic aromatic amines and sensory quality of pan-fried beef, Food Chemistry, vol.122, issue.1, pp.98-104, 2010.

F. Quintus, O. Sperandio, J. Grynberg, M. Petitjean, and P. Tuffery, Ligand scaffold hopping combining 3D maximal substructure search and molecular similarity, BMC Bioinformatics, vol.10, issue.1, p.245, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00663937

D. J. Rogers and T. T. Tanimoto, A Computer Program for Classifying Plants, Science, vol.132, issue.3434, pp.1115-1118, 1960.

R. Salazar, G. Arámbula-villa, F. J. Hidalgo, and R. Zamora, Structural characteristics that determine the inhibitory role of phenolic compounds on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation, Food Chemistry, vol.151, pp.480-486, 2014.

O. Sperandio, M. Petitjean, and P. Tuffery, wwLigCSRre: a 3D ligand-based server for hit identification and optimization, Nucleic Acids Research, vol.37, issue.Web Server, pp.W504-W509, 2009.

T. Sterling and J. J. Irwin, ZINC 15 ? Ligand Discovery for Everyone, Journal of Chemical Information and Modeling, vol.55, issue.11, pp.2324-2337, 2015.

U. Stervbo, O. Vang, and C. Bonnesen, A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine, Food Chemistry, vol.101, issue.2, pp.449-457, 2007.

M. M. Tengilimoglu-metin, A. Hamzalioglu, V. Gokmen, and M. Kizil, Inhibitory effect of hawthorn extract on heterocyclic aromatic amine formation in beef and chicken breast meat, Food Research International, vol.99, issue.1, pp.586-595, 2017.

C. Kevers, J. Pincemail, J. O. Defraigne, and J. Dommes, Antioxidant capacity 755 and phenolic composition of red wines from various grape varieties: Specificity of 756, 2014.

R. Van-leeuw, C. Kevers, J. Pincemail, J. O. Defraigne, and J. Dommes, Antioxidant capacity and phenolic composition of red wines from various grape varieties: Specificity of Pinot Noir, Journal of Food Composition and Analysis, vol.36, issue.1-2, pp.40-50, 2014.

C. G. Wermuth, Analog Design, vol.7, pp.167-179, 2010.

M. Zeng, Y. Li, Z. He, F. Qin, G. Tao et al., Discrimination and investigation of inhibitory patterns of flavonoids and phenolic acids on heterocyclic amine formation in chemical model systems by UPLC-MS profiling and chemometrics, European Food Research and Technology, vol.242, issue.3, pp.313-319, 2015.

W. Zheng and S. Lee, Well-Done Meat Intake, Heterocyclic Amine Exposure, and Cancer Risk, Nutrition and Cancer, vol.61, issue.4, pp.437-446, 2009.

Q. Zhu, S. Zhang, M. F. Wang, J. Chen, and Z. P. Zheng, Inhibitory effects of selected dietary flavonoids on the formation of total heterocyclic amines and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in roast beef patties and in chemical models, Food & Function, vol.7, issue.2, pp.1057-1066, 2016.

M. Maïa, Conceptualization, Methodology, p.776

J. Carpenter, Writing effective project proposals, Library Project Funding, pp.175-212, 2008.

A. Magaly,

M. Frédéric, Mercier, Frédéric, 2011.

R. M. Patrick and M. Camac, EXPERIMENTAL INVESTIGATION OF COLLISION-FREE SHOCKS AND PLASMAS, 1961.

C. Laurent, Writing -Review & Editing

, Chevolleau, Jean, Sylvie CHEVOLLEAU-Investigation, Resources, Writing -Review & Editing, 2011.

B. Carroll, Editing for Digital Media, Writing and Editing for Digital Media, pp.29-58, 2017.

E. Engel--conceptualization, Devé, Philippe Erwan, Formal analysis, 2011.

D. Puzzo, J. Fiorito, R. Purgatorio, W. Gulisano, A. Palmeri et al., Molecular Mechanisms of Learning and Memory**The authors declare no competing financial interests., Genes, Environment and Alzheimer's Disease, pp.1-27, 2016.

D. Puzzo, J. Fiorito, R. Purgatorio, W. Gulisano, A. Palmeri et al., Molecular Mechanisms of Learning and Memory**The authors declare no competing financial interests., Genes, Environment and Alzheimer's Disease, pp.1-27, 2016.

S. Ng, Freeze?Dried Wafers for Wound Healing, pp.137-155, 2020.

N. D. , Supplementary file 1. Significant gene expression differences between POMC- and NPY-expressing neurons., p.856