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A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations

Abstract : The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.
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https://hal.inrae.fr/hal-02899584
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Submitted on : Thursday, October 8, 2020 - 9:39:11 AM
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José Lima-Barbero, Marinela Contreras, Lourdes Mateos-Hernandez, Francisco Mata-Lorenzo, Roxana Triguero-Ocaña, et al.. A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations. Vaccines, MDPI, 2019, 7 (4), pp.190. ⟨10.3390/vaccines7040190⟩. ⟨hal-02899584⟩

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