Skip to Main content Skip to Navigation
Journal articles

Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm

Abstract : Retinoic acid (RA) signalling ensures that vertebrate mesoderm segmentation is bilaterally synchronized, and corrects transient interferences from asymmetric left-right (L-R) signals involved in organ lateralization. Snail genes participate in both these processes and, although they are expressed symmetrically in the presomitic mesoderm (PSM), Snail1 transcripts are asymmetrically distributed in the L-R lateral mesoderm. We show that the alteration of the symmetric Snail expression in the PSM induces asynchronous somite formation. Furthermore, in the absence of RA signalling, normal asymmetric Snail1 expression in the lateral mesoderm is extended to the PSM, desynchronizing somito-genesis. Thus, Snail1 is the first cue corrected by RA in the PSM to ensure synchronized bilateral segmentation.
Complete list of metadata

Cited literature [27 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02912731
Contributor : Hervé Acloque <>
Submitted on : Thursday, August 6, 2020 - 3:24:31 PM
Last modification on : Friday, October 2, 2020 - 10:34:24 AM

Links full text

Identifiers

Collections

Citation

& Nieto, Aixa Morales, Hervé Acloque, Oscar Ocana, Cristina de Frutos, et al.. Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm. EMBO Reports, EMBO Press, 2006, 8 (1), pp.104-109. ⟨10.1038/sj.embor.7400867⟩. ⟨hal-02912731⟩

Share

Metrics

Record views

14