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Modifications ciblées des génomes : Apports et impacts potentiels des nouvelles technologies pour les espèces aviaires

Abstract : The advent of designer nucleases, especially CRISPR-Cas9, is providing a real breakthrough in genome editing technology. The principle is simple : Double-strand breaks (DSB) are accurately produced on selected target DNA sequences in specific cells. These DSB are then repaired by non-homologous end-joining, resulting in inactivation of the targeted gene(s), or by inserting a specific DNA fragment (template) through homologous recombination. These technologies can be used in multiple domains, including fundamental research, gene therapy, ecological engineering, biotechnologies or agriculture. Examples are presented of research projects aiming at improving animal health, avoiding controversial breeding practices, or improving the health impact and/or nutritional values of animal products. Numerous questions raised by the use of these technologies (techniques, regulation, economics, ethics…) are discussed. Key-Words : CRISPR, genome editing, poultry
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https://hal.inrae.fr/hal-02912741
Contributor : Bertrand Bed'Hom <>
Submitted on : Thursday, October 22, 2020 - 11:39:51 AM
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Alain Ducos, Bertrand Bed'Hom, Hervé Acloque, Bertrand Pain. Modifications ciblées des génomes : Apports et impacts potentiels des nouvelles technologies pour les espèces aviaires. Bulletin de l'Académie Vétérinaire de France, Académie vétérinaire de France, A paraître, ⟨10.3406/bavf.2020.70900⟩. ⟨hal-02912741v2⟩

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