, European Union Reference Laboratory for GM

, Institute for Reference Materials and Measurements : l'un des sept instituts du laboratoire de référence communautaire

, La directive 2001/18/CE est une directive du Parlement européen et du Conseil du 12 mars 2001 qui fixe les règles communautaires relatives à la dissémination volontaire d'OGM dans l'environnement. Elle abroge la directive 90/220/CEE du Conseil

L. Règlement, Scientific opinion on Statistical considerations for the safety evaluation of GMOs, on request of EFSA, question n° EFSA-Q-2006-080, CE) 1830/2003 est un règlement du Parlement européen et du Conseil du 22 septembre 2003 concernant la traçabilité et l'étiquetage des organismes génétiquement modifiés et la traçabilité des produits destinés à l'alimentation humaine ou animale produits à partir d'organismes génétiquement modifiés, vol.18, p.1250, 2001.

T. Funke, H. Han, M. L. Healy-fried, M. Fischer, and E. Schonbrunn, Molecular basis for the herbicide resistance of Roundup Ready crops, Proc Natl Acad Sci U S A, vol.103, pp.13010-13015, 2006.

B. E. Goertz, Assessment of the in vitro digestibility of the Cry 1Ac protein in simulated gastric and simulated intestinal fluids, Confidential Report MSL 0021376, 2008.

L. A. Harrison, M. R. Bailey, M. W. Naylor, J. E. Ream, B. G. Hammond et al., The expressed protein in glyphosate-tolerant soybean, 5-enolypyruvylshikimate-3-phosphate synthase from Agrobacterium sp strain CP4, is rapidly digested in vitro and is not toxic to acutely gavaged mice, J Nutr, vol.126, pp.728-740, 1996.

J. N. Leach, Assessment of the in vitro digestibility of purified E-Coli-produced CP4 EPSPS protein in simulated gastric fluid, 2002.

S. C. Macintosh, T. B. Stone, S. R. Sims, P. L. Hunst, J. T. Greenplate et al., Specificity and efficacy of purified Bacillus thuringiensis proteins against agronomically important insects, J Invertebr Pathol, vol.56, pp.258-266, 1990.

D. J. Matthews and P. Hayes, Effect of temperature on germination and emergence of six cultivars of soybean (Glycine max, Seed Science and Technology, vol.10, pp.547-555, 1982.

R. L. Mccoy and A. Silvanovich, Bioinformatics analysis of the CP4 EPSPS protein utilizing the AD4, Toxin5 and ALLPEPTIDES databases, 2003.

M. W. Naylor, One month feeding study with processed glyphosate-tolerant soybean meal in Sprague Dawley rats, 1993.

C. Planchon, Le soja : Physiologie de la plante et adaptation aux conditions françaises, CETIOM-INRA, 1986.

J. Ray, T. C. Kilen, C. A. Abel, and R. L. Paris, Soybean natural cross-pollination rates under field conditions, Environ Biosafety Res, vol.2, pp.133-138, 2003.

A. Silvanovich, Updated bioinformatic evaluation of the DNA sequences flanking the insertion site in MON 87701 (BLASTn/x analyses) and of DNA sequences flanking the 5' and 3' junctions of the inserted DNA in MON 89788 (assessment of putative polypeptides utilizing PRT_09 database), 2009.

, Confidential report

S. Sivakumar, R. Rajagopal, G. R. Venkatesh, A. Srivastava, and R. K. Bhatnagar, , 2007.

, Knockdown of aminopeptidase-N from Helicoverpa armigera larvae and in transfected Sf21 cells by RNA interference reveals its functional interaction with Bacillus thuringiensis insecticidal protein Cry1Ac, J Biol Chem, vol.282, pp.7312-7319

J. W. Smedley, An acute oral toxicity study of Cry1Ac administered by the oral (gavage) route in mice, Confidential report n° CRO, pp.2007-325, 2009.

M. Soberon, S. S. Gill, and A. Bravo, Signaling versus punching hole: How do Bacillus thuringiensis toxins kill insect midgut cells?, Cell Mol Life Sci, vol.66, pp.1337-1349, 2009.

E. A. Tambussi, C. G. Bartoli, J. J. Guiamet, J. Beltrano, and J. L. Araus, Oxidative stress and photodamage at low temperatures in soybean (Glycine max L. Merr.) leaves, Plant Sci, vol.167, pp.19-26, 2004.

D. W. Unander, J. W. Lambert, and J. H. Orf, Cool temperature soybean germination: Genetic and environmental components, pp.83-84, 1983.

R. Xie, M. Zhuang, L. S. Ross, I. Gomez, D. I. Oltean et al., Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins, J Biol Chem, vol.280, pp.8416-8425, 2005.

L. Hcb and C. De,

J. Pagès, J. Président, . Leguay, Y. Vice-président, P. Bertheau et al.,

X. Un-rapporteur-extérieur, . Pinochet, and C. Du, Pinochet a signé un engagement de confidentialité, et a certifié son absence de conflits d'intérêts après avoir pris connaissance du dossier. Il a fourni une analyse du dossier dans son domaine d'expertise, et a été auditionné par le CS