A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Viruses Année : 2020

A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses

Javier A. Jaimes
Jean Millet
Alison E. Stout
Nicole M. André

Résumé

Feline coronavirus (FCoV) is a complex viral agent that causes a variety of clinical manifestations in cats, commonly known as feline infectious peritonitis (FIP). It is recognized that FCoV can occur in two different serotypes. However, differences in the S protein are much more than serological or antigenic variants, resulting in the effective presence of two distinct viruses. Here, we review the distinct differences in the S proteins of these viruses, which are likely to translate into distinct biological outcomes. We introduce a new concept related to the non-taxonomical classification and differentiation among FCoVs by analyzing and comparing the genetic, structural, and functional characteristics of FCoV and the FCoV S protein among the two serotypes and FCoV biotypes. Based on our analysis, we suggest that our understanding of FIP needs to consider whether the presence of these two distinct viruses has implications in clinical settings.
Fichier principal
Vignette du fichier
viruses-12-00083.pdf (3.75 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-02919879 , version 1 (07-06-2023)

Licence

Paternité

Identifiants

Citer

Javier A. Jaimes, Jean Millet, Alison E. Stout, Nicole M. André, Gary R. Whittaker. A Tale of Two Viruses: The Distinct Spike Glycoproteins of Feline Coronaviruses. Viruses, 2020, 12 (1), pp.83. ⟨10.3390/v12010083⟩. ⟨hal-02919879⟩
22 Consultations
3 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More