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M. L. , was supported by grant P41-GM103313 and R01-GM095485 from the NIH (US) to the University of Connecticut School of Medicine. J. ? C. was supported by the Czech Research Infrastructure Infrastructure for Systems Biology C4SYS, 2015055.

. Ga-?-cr,

D. Anr and F. ). Inria, Liver Systems Medicine) from Bundesministerium fü r Bildung und Forschung (BMBF, Germany) to IfADo, Dortmund, Germany; by grant VLN (Virtual Liver Network) from Bundesministerium fü r Bildung und Forschung (BMBF, Germany) to IfADo, Dortmund, Germany; by grant Physicancer from Institut national de la santé et de la recherche mé dicale (INSERM, France) to INRIA, .E. was supported by CHARME, COST, Action CA15110 MoU, p.10429

A. , was supported by the Japanese Society for the Promotion of Science. M.G. was supported by funding to HITS from the German Federal Ministry of Education and Research (BMBF) as part of the Liver Systems Medicine Network LiSyM (FKZ 031L0056) and through the MulticellML project (FKZ 01ZX1707B), as well as from the European Union Horizon2020 framework programme of the European Commission under Grant Agreement 825843 and from the Klaus Tschira Foundation (KTS)

M. G. , was supported by European Molecular Biology Laboratory (EMBL) core funding. W.S.H. was supported by grant R01-GM111510 from the National Institute of, General Medical Sciences

D. K. , was supported by Novo Nordisk Foundation grant NNF10CC1016517. E.K. was supported by Deutsche Forschungsgemeinschaft (DFG, GRK1772, GRK 2290 and TRR175) and by People Programme (Marie Sk?odowska-Curie Actions

F. , was supported by the Russian Foundation for Basic Research

J. , US) to the Icahn School of Medicine. P.K. was supported by NIH grant GM075742 from the NIH (US) to SRI International. S.K. was supported by grant 031L104B (de.NBI partner project "ModSim") by the German Federal Ministry of Education and Research to MPI Magdeburg. L.M.L. was supported by grant P41-GM103313 from the NIH (US) to the University of Connecticut School of Medicine, was supported by grants R35-GM119771 and P41-EB023912 from the NIH

, Tecnologia (FCT) to INESC-ID. A.P.'s contribution to this manuscript is a follow-up of the work done while employed at Virginia Tech. (VA, US). The opinions expressed in this manuscript are the authors' own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States Government

, License: This is an open access article under the terms of the Creative Commons Attribution

, License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited

, California Institute of Technology Published under the terms of the CC BY 4, Molecular Systems Biology, vol.16, 2020.