Response of Chinese hamster ovary cells to a Cytolethal Distending Toxin (CDT) of Escherichia coli and possible misinterpretation as heat-labile (LT) enterotoxin, FEMS Microbiol. Lett, vol.43, pp.19-23, 1987. ,
A new heat-labile Cytolethal Distending Toxin (CLDT) produced by Campylobacter spp, Microb. Pathog, vol.4, pp.115-126, 1988. ,
Identification of a Cytolethal Distending Toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans, Infect. Immun, vol.67, pp.1227-1237, 1999. ,
The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a Cytolethal Distending Toxin, Infect. Immun, vol.66, pp.5008-5019, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-02686328
A diffusible cytotoxin of Haemophilus ducreyi, Proc. Natl. Acad. Sci, vol.94, pp.4056-4061, 1997. ,
Cytolethal distending Toxin: A conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages, Microbiology, vol.157, pp.1851-1875, 2011. ,
Examination of diarrheagenicity of Cytolethal Distending Toxin: Suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae, Infect. Immun, vol.65, pp.428-433, 1997. ,
Gastroenteritis in NF-B-Deficient Mice Is Produced with Wild-Type Camplyobacter jejuni but Not with C. jejuni Lacking Cytolethal Distending Toxin despite Persistent Colonization with Both Strains, Infect. Immun, vol.72, pp.1116-1125, 2004. ,
Cytolethal Distending Toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice, Infect. Immun, vol.73, pp.3559-3567, 2005. ,
Differences in virulence attributes between cytolethal distending toxin positive and negative Campylobacter jejuni strains, J. Med. Microbiol, vol.57, pp.267-272, 2008. ,
Modulation of host immune responses by the Cytolethal Distending Toxin of Helicobacter hepaticus, Infect. Immun, vol.74, pp.4496-4504, 2006. ,
In vitro and in vivo characterization of helicobacter hepaticus Cytolethal Distending Toxin mutants, Infect. Immun, vol.72, pp.2521-2527, 2004. ,
Bacterial Cytolethal Distending Toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis, Cell. Microbiol, vol.9, pp.2070-2080, 2007. ,
Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129 ag2 -deficient mice, Cell. Microbiol, vol.19, pp.1-11, 2017. ,
Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin, Gut, vol.68, pp.289-300, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02627995
Cytolethal Distending Toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells, Infect. Immun, vol.67, pp.6394-6402, 1999. ,
Actinobacillus actinomycetemcomitans toxin induces both cell cycle arrest in the G2/M phase and apoptosis, Infect. Immun, vol.66, pp.5980-5987, 1998. ,
The Haemophilus ducreyi Cytolethal Distending Toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA, Cell. Microbiol, vol.5, pp.695-707, 2003. ,
From single-strand breaks to double-strand breaks during S-phase: A new mode of action of the Escherichia coli Cytolethal Distending Toxin: A new mode of action for CDT, Cell. Microbiol, vol.15, pp.1-15, 2013. ,
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms, Sci. Rep, vol.6, pp.1-15, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01602345
The Haemophilus ducreyi Cytolethal Distending Toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells, Cell. Microbiol, vol.4, pp.87-99, 2002. ,
Escherichia coli Cytolethal Distending Toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation, Infect. Immun, vol.65, pp.508-5095, 1997. ,
URL : https://hal.archives-ouvertes.fr/hal-02695472
A new Cytolethal Distending Toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase, Mol. Microbiol, vol.24, pp.1095-1107, 1997. ,
URL : https://hal.archives-ouvertes.fr/hal-02648882
Assembly and function of a bacterial genotoxin, Nature, vol.429, pp.429-433, 2004. ,
Cloning, sequencing, and expression of the Escherichia coli Cytolethal Distending Toxin genes, Infect. Immun, vol.62, pp.1046-1051, 1994. ,
Cloning and sequencing of the genes encoding Escherichia coli Cytolethal Distending Toxin, Infect. Immun, vol.62, pp.244-251, 1994. ,
Localization of Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin subunits during intoxication of live cells, Infect. Immun, vol.80, pp.2761-2770, 2012. ,
Bacterial genotoxins: The long journey to the nucleus of mammalian cells, Biochim. Biophys. Acta -Biomembr, vol.1858, pp.567-575, 2016. ,
Structure and function of the Salmonella Typhi chimaeric A 2 B 5 typhoid toxin, Nature, vol.499, pp.350-354, 2013. ,
Escherichia coli CdtB mediates Cytolethal Distending Toxin cell cycle arrest, Infect. Immun, vol.69, pp.3418-3422, 2001. ,
Contribution of Helicobacter hepaticus Cytolethal distending toxin subunits to human epithelial cell cycle arrest and apoptotic death in vitro, Helicobacter, vol.18, pp.433-443, 2013. ,
Carbohydrate-binding specificity of the Escherichia coli Cytolethal Distending Toxin CdtA-II and CdtC-II subunits, Infect. Immun, vol.73, pp.2051-2060, 2005. ,
Toxic activity of the CdtB component of Haemophilus ducreyi cytolethal distending toxin expressed from an adenovirus 5 vector, APMIS, vol.118, pp.143-149, 2010. ,
Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not, PLoS ONE, vol.14, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02346660
Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway, Proc. Natl. Acad. Sci, vol.101, pp.4614-4619, 2004. ,
A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein, vol.290, pp.354-357, 2000. ,
Functional studies of the recombinant subunits of a cytolethal distending holotoxin, Cell. Microbiol, vol.4, pp.245-255, 2002. ,
An N-terminal segment of the active component of the bacterial genotoxin Cytolethal Distending Toxin B (CDTB) directs CDTB into the nucleus, J. Biol. Chem, vol.278, pp.50671-50681, 2003. ,
URL : https://hal.archives-ouvertes.fr/hal-02682070
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): Crystal structure of CDT from Actinobacillus actinomycetemcomitans, Protein Sci, vol.15, pp.362-372, 2006. ,
DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest, Mol. Microbiol, vol.37, pp.952-963, 2000. ,
Functionally unrelated signalling proteins contain a fold similar to Mg 2+ -dependent endonucleases, Trends Biochem. Sci, vol.25, pp.272-273, 2000. ,
Differences in crystal and solution structures of the Cytolethal Distending Toxin B subunit, J. Biol. Chem, vol.281, pp.25365-25372, 2006. ,
Engineering hyperactive variants of human deoxyribonuclease i by altering its functional mechanism, Biochemistry, vol.36, pp.6624-6632, 1997. ,
Expression and activity of the cytolethal distending toxin of Helicobacter hepaticus, Biochem. Biophys. Res. Commun, vol.318, pp.739-745, 2004. ,
The cytolethal distending toxin B sub-unit of Helicobacter hepaticus is a Ca 2+ -and Mg 2+ -dependent neutral nuclease, FEMS Microbiol. Lett, pp.219-225, 2005. ,
Cytolethal Distending Toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts, DNA Repair, vol.18, pp.31-43, 2014. ,
Bacterial genotoxins: Merging the DNA damage response into infection biology, vol.5, pp.1762-1782, 2015. ,
A novel mode of action for a microbial-derived immunotoxin: The Cytolethal Distending Toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity, J. Immunol, vol.178, pp.5099-5108, 2007. ,
The toxicity of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity: Cdt toxicity is dependent on PIP 3 phosphatase activity, Cell. Microbiol, vol.18, pp.223-243, 2015. ,
A Cytolethal Distending Toxin variant from Aggregatibacter actinomycetemcomitans with an aberrant CdtB that lacks the conserved catalytic Histidine 160, PLoS ONE, vol.11, 2016. ,
Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin induces apoptosis in non-proliferating macrophages by a phosphatase-independent mechanism, Infect. Immun, vol.77, pp.3161-3169, 2009. ,
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases, Structure, vol.22, pp.744-755, 2014. ,
Suck, D. DNase I-induced DNA conformation, J. Mol. Biol, vol.222, pp.645-667, 1991. ,
Cellular internalization of cytolethal distending toxin: A new end to a known pathway: Internalization of bacterial toxin, Cell. Microbiol, vol.7, pp.921-934, 2005. ,
Cytolethal Distending Toxin subunit B: A review of structure-function relationship, Toxins, vol.11, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02618477
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139, J. Biol. Chem, vol.273, pp.5858-5868, 1998. ,
Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells, J. Cell Sci, vol.129, pp.2673-2683, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01602858
Characterisation of cytolethal distending toxin (CDT) mutants of Campylobacter jejuni, J. Med. Microbiol, vol.49, pp.473-479, 2000. ,
Cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Occurrence and association with periodontal disease, J. Periodontal Res, vol.37, pp.268-272, 2002. ,
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate, Nature, vol.499, pp.233-237, 2013. ,
AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells, Cell Death Dis, vol.8, pp.1-14, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02735083
The Cytolethal Distending Toxin subunit CdtB of Helicobacter hepaticus promotes senescence and endoreplication in xenograft mouse models of hepatic and intestinal cell lines, Front. Cell. Infect. Microbiol, vol.7, pp.1-14, 2017. ,
DNA damage causes rapid accumulation of phosphoinositides for ATR signaling, Nat. Commun, 2017. ,
TOP2?-dependent nuclear DNA damage shapes extracellular growth factor responses via dynamic AKT phosphorylation to control virus latency, Mol. Cell, vol.74, 2019. ,
Full Activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM, J. Biol. Chem, vol.280, pp.4029-4036, 2005. ,
Quantitative lipid imaging reveals a new signaling function of phosphatidylinositol-3,4-bisphophate: Isoformand site-specific activation of Akt, Mol. Cell, vol.71, pp.1092-1104, 2018. ,
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate, Mol. Oral Microbiol, vol.31, pp.33-42, 2016. ,
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer, Sci. Rep, vol.8, p.3947, 2018. ,
The functions and regulation of the PTEN tumour suppressor: New modes and prospects, Nat. Rev. Mol. Cell Biol, vol.19, pp.547-562, 2018. ,
The Cytolethal Distending Toxin effects on mammalian cells: A DNA damage perspective, vol.3, pp.592-615, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01192559
Cytolethal Distending Toxin family members are differentially affected by alterations in host glycans and membrane cholesterol, J. Biol. Chem, vol.285, pp.18199-18207, 2010. ,
, This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, © 2020 by the authors. Licensee MDPI