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Chapitre d'ouvrage

Regulating Bacterial Virulence with RNA

Abstract : Noncoding RNAs (ncRNAs) regulating virulence have been identified in most pathogens. This review discusses RNA-mediated mechanisms exploited by bacterial pathogens to successfully infect and colonize their hosts. It discusses the most representative RNA-mediated regulatory mechanisms employed by two intracellular [Listeria monocytogenes and Salmonella enterica serovar Typhimurium (S. Typhimurium)] and two extracellular (Vibrio cholerae and Staphylococcus aureus) bacterial pathogens. We review the RNA-mediated regulators (e.g., thermosensors, riboswitches, cis- and transencoded RNAs) used for adaptation to the specific niches colonized by these bacteria (intestine, blood, or the intracellular environment, for example) in the framework of the specific pathophysiological aspects of the diseases caused by these microorganisms. A critical discussion of the newest findings in the field of bacterial ncRNAs shows how examples in model pathogens could pave the way for the discovery of new mechanisms in other medically important bacterial pathogens.
Mots-clés : excludon regulation
Type de document :
Chapitre d'ouvrage
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Déposant : Migration Prodinra <>
Soumis le : mercredi 2 septembre 2020 - 12:50:09
Dernière modification le : jeudi 3 septembre 2020 - 03:12:03


  • HAL Id : hal-02928225, version 1
  • PRODINRA : 415278
  • WOS : 000411800600015



Juan J. Quereda, Pascale Cossart. Regulating Bacterial Virulence with RNA. Annual Review of Microbiology, 71, ANNUAL REVIEWS, pp.18, 2017, Annual Review of Microbiology, 978-0-8243-1171-1. ⟨hal-02928225⟩



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