Skip to Main content Skip to Navigation
Journal articles

Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles

Daniele Santi 1, 2 Pascale Crepieux 3, 4 Eric Reiter 3, 4 Giorgia Spaggiari 2 Giulia Brigante 1, 2 Livio Casarini 1 Vincenzo Rochira 1, 2 Manuela Simoni 1, 2, 3, *
* Corresponding author
4 MUSCA - Dynamiques de populations multi-échelles pour des systèmes physiologiques
Inria Saclay - Ile de France, PRC - Physiologie de la reproduction et des comportements [Nouzilly], MaIAGE - Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas]
Abstract : Background: Human reproduction is regulated by the combined action of the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH is largely used in female reproduction, in particular in women attending assisted reproductive techniques to stimulate multi-follicular growth, its efficacy in men with idiopathic infertility is not clearly demonstrated. Indeed, whether FSH administration improves fertility in patients with hypogonadotropic hypogonadism, the therapeutic benefit in men presenting alterations in sperm production despite normal FSH serum levels is still unclear. In the present review, we evaluate the potential pharmacological benefits of FSH administration in clinical practice. Methods: This is a narrative review, describing the FSH physiological role in spermatogenesis and its potential therapeutic action in men. Results: The FSH role on male fertility is reviewed starting from the physiological control of spermatogenesis, throughout its mechanism of action in Sertoli cells, the genetic regulation of its action on spermatogenesis, until the therapeutic options available to improve sperm production. Conclusion: FSH administration in infertile men has potential benefits, although its action should be considered by evaluating its synergic action with testosterone, and well-controlled, powerful trials are required. Prospective studies and new compounds could be developed in the near future.
Document type :
Journal articles
Complete list of metadata
Contributor : Christopher Lallemant <>
Submitted on : Friday, September 4, 2020 - 11:47:33 AM
Last modification on : Wednesday, June 2, 2021 - 3:28:02 PM

Links full text



Daniele Santi, Pascale Crepieux, Eric Reiter, Giorgia Spaggiari, Giulia Brigante, et al.. Follicle-Stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles. Journal of Clinical Medicine, MDPI, 2020, 9 (4), pp.1014. ⟨10.3390/jcm9041014⟩. ⟨hal-02930237⟩



Record views