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Microbiote et cancer colorectal : des bactéries génotoxiques dans le tractus intestinal

Abstract : Numerous studies support a role for the intestinal microbiota in colorectal tumorigenesis. Although colon cancer has not yet been epidemiologically linked to specific bacterial species, recent results suggest that certain toxigenic commensal bacteria may be oncogenic Strains of Escherichia coli, a ubiquitous member of the colonic flora, synthesize a genotoxin called colibactin. These bacteria induce DNA double-strand breaks in intestinal cells and trigger chromosomal instability, gene mutations and cell transformation. Thus, long-term colonization of the colon by rogue commensal bacteria capable of causing chronic DNA damage could contribute to the development of sporadic colorectal cancer.
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https://hal.inrae.fr/hal-02935503
Contributor : Nougayrede Jean-Philippe <>
Submitted on : Thursday, September 10, 2020 - 1:55:41 PM
Last modification on : Friday, June 4, 2021 - 4:44:01 PM

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  • HAL Id : hal-02935503, version 1
  • PUBMED : 22530520

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Jean-Philippe Nougayrède, Eric Oswald. Microbiote et cancer colorectal : des bactéries génotoxiques dans le tractus intestinal. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2011, 195 (6), pp.1295-304; discussion 1304-5. ⟨hal-02935503⟩

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