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Maternally acquired genotoxic Escherichia coli alters offspring’s intestinal homeostasis

Abstract : The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coil strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coil from mothers to neonates. Genotoxic and non-genotoxic E. con strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage was only detected in neonates colonized with genotoxic E. coil strains. Signs of genotoxic stress such as anaphase bridges, higher occurrence of crypt fission and accelerated renewal of the mature epithelium were detected at adulthood. In addition, we observed alterations of secretory cell populations and gut epithelial barrier. Our findings illustrate how critical is the genotype of E. con strains acquired at birth for gut homeostasis at adulthood.
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https://hal.inrae.fr/hal-02935531
Déposant : Nougayrede Jean-Philippe <>
Soumis le : jeudi 10 septembre 2020 - 14:13:56
Dernière modification le : vendredi 18 septembre 2020 - 03:28:52

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Delphine Payros, Thomas Secher, Michèle Boury, Camille Brehin, Sandrine Ménard, et al.. Maternally acquired genotoxic Escherichia coli alters offspring’s intestinal homeostasis. Gut microbes, Taylor & Francis, 2014, 5 (3), pp.313-512. ⟨10.4161/gmic.28932⟩. ⟨hal-02935531⟩

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