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Article dans une revue

Common Pathological Mechanisms and Risk Factors for Alzheimer’s Disease and Type-2 Diabetes: Focus on Inflammation

Abstract : Background: Diabetes is considered as a risk factor for Alzheimer's Disease, but it is yet tinclear whether this pathological link is reciprocal. Although Alzheimer's disease and diabetes appear as entirely different pathological entities affecting the Central Nervous System and a peripheral organ (pancreas), respectively, they share a common pathological core. Recent evidence suggests that in the pancreas in the case of diabetes, as in the brain for Alzheimer's Disease, the initial pathological event may be the accumulation of toxic proteins yielding amyloidosis. Moreover, in both pathologies, amyloidosis is likely responsible for local inflammation, which acts as a driving force for cell death and tissue degeneration. These pathological events are all inter-connected and establish a vicious cycle resulting in the progressive character of both pathologies.
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Article dans une revue
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https://hal.inrae.fr/hal-02938710
Déposant : Christopher Lallemant <>
Soumis le : mardi 15 septembre 2020 - 09:51:27
Dernière modification le : mercredi 16 septembre 2020 - 17:51:41

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Emmanuel Moyse, Mohamed Haddad, Camelia Benlabiod, Charles Ramassamy, Slavica Krantic. Common Pathological Mechanisms and Risk Factors for Alzheimer’s Disease and Type-2 Diabetes: Focus on Inflammation. Current Alzheimer Research, Bentham Science Publishers, 2019, 16 (11), pp.986-1006. ⟨10.2174/1567205016666191106094356⟩. ⟨hal-02938710⟩

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