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Bacterial growth physiology and RNA metabolism

Abstract : Bacteria are sophisticated systems with high capacity and flexibility to adaptto various environmental conditions. Each prokaryote how ever possesses a defined metabolicnetwork,whichsetsitsoverallmetaboliccapacity,andthereforethemaximalgrowthratethatcanbereached. Toachieve optimal growth, bacteria adopt various molecular strategies to optimally adjust gene expression and optimize resource allocation according to the nutrient availability. There sulting physiological changes are often accompanied by changes in the growth rate, and by global regulation of gene expression. The growth-rate-dependent variation of the abundances in the cellular machineries, together with condition-specific regulatory mechanisms, affect RNA metabolism and fate and pose a challenge forrational gene expression reengineering of synthetic circuits. This article is part of a Special Issue entitled: RNA and gene control in bacteria, edited by Dr. M. Guillierand F. Repoila.
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https://hal.inrae.fr/hal-02940832
Contributor : Anne-Gaëlle Planson <>
Submitted on : Wednesday, September 16, 2020 - 3:40:25 PM
Last modification on : Wednesday, June 2, 2021 - 5:36:02 PM

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Anne-Gaëlle Planson, Vincent Sauveplane, Etienne Dervyn, Matthieu Jules. Bacterial growth physiology and RNA metabolism. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , Elsevier, 2020, 1863 (5), pp.194502. ⟨10.1016/j.bbagrm.2020.194502⟩. ⟨hal-02940832⟩

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