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Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion

Abstract : The intake of processed meat has been associated with several adverse health outcomes such as type II diabetes and cancer; however, the mechanisms are not fully understood. A better knowledge of the metabolite profiles of di erent processed and non-processed meat products from this heterogeneous food group could help in elucidating the mechanisms associated with these health e ects. Thirty-three di erent commercial samples of ten processed and non-processed meat products were digested in triplicate with a standardized static in vitro digestion method in order to mimic profiles of small molecules formed in the gut upon digestion. A metabolomics approach based on high-resolution mass spectrometry was used to identify metabolite profiles specific to the various meat products. Processed meat products showed metabolite profiles clearly distinct from those of non-processed meat. Several discriminant features related to either specific ingredients or processing methods were identified. Those were, in particular, syringol compounds deposited in meat during smoking, biogenic amines formed during meat fermentation and piperine and related compounds characteristic of pepper used as an ingredient. These metabolites, characteristic of specific processed meat products, might be used as potential biomarkers of intake for these foods. They may also help in understanding the mechanisms linking processed meat intake and adverse health outcomes such as cancer.
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Contributor : Sabine Rossi <>
Submitted on : Thursday, September 24, 2020 - 9:38:54 AM
Last modification on : Wednesday, October 14, 2020 - 4:07:58 AM

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Roland Wedekind, Pekka Keski-Rahkonen, Nivonirina Robinot, Frédéric Mercier, Erwan Engel, et al.. Metabolic Signatures of 10 Processed and Non-processed Meat Products after In Vitro Digestion. Metabolites, MDPI, 2020, 10 (7), pp.272. ⟨10.3390/metabo10070272⟩. ⟨hal-02947711⟩



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